Generic Name and Formulations:
Zolpidem tartrate 5mg per metered actuation (one spray) in 100microliter; oral solution spray; cherry-flavor.
Indications for ZOLPIMIST:
Short-term treatment of insomnia characterized by difficulties with sleep initiation.
Individualize. Give once daily immediately before bedtime. 10mg (two actuations). Max 10mg/day. Elderly, debilitated, or hepatic impaired: 5mg (one actuation); monitor closely. Concomitant CNS depressants: use downward dose adjustments. Effects delayed if used with or immediately after a meal.
Evaluate for co-morbid diagnoses (eg, physical and/or psychiatric disorders) prior to treatment. Reevaluate if insomnia persists after 7–10 days of use. Monitor for new onset behavioral changes, worsening of depression, or suicidal thinking. Hepatic impairment. Conditions that affect metabolism or hemodynamic response. Compromised respiratory function. Sleep apnea. Myasthenia gravis. Drug abusers. Write ℞ for smallest practical amount. Withdraw gradually. Debilitated. Elderly. Pregnancy (Cat.C). Nursing mothers.
Additive effects with concomitant other CNS depressants (eg, imipramine, chlorpromazine), or alcohol (avoid); reduce dose. Potentiated by potent CYP3A4 inhibitors (eg, ketoconazole); reduce zolpidem dose. Antagonized by CYP3A4 inducers (eg, rifampin).
Drowsiness, dizziness, diarrhea, drugged feeling, headache; abnormal thinking, behavioral changes, complex behaviors (eg, sleep-driving), hallucinations, amnesia, anxiety, other neuropsychiatric symptoms; anaphylaxis, angioedema.
Pump (60 metered actuations)—1
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Adjunctive Therapies for Bipolar Disorder Show Promise, Need More Evidence
- Predicting Treatment-Emergent Mania to Tailor Pharmacotherapy in Bipolar Disorder
- Abnormalities of Cortical Thickness in Bipolar Disorder With Auditory Hallucinations
- Prevalence of ADHD Relatively Stable Over Time Despite Increase in Diagnoses
- Genetic Variations Associated With Empathy Affect Psychiatric Conditions
- The Way to the Head May Be Through the Gut: Probiotics for Depression
- Suicide-Screening Toolkit Can Help Identify Youths at High Risk for Suicide
- Agoraphobia: An Evolving Understanding of Definitions and Treatment
- Parental Pressure to Diet Linked With Long-term Harm in Adolescents
- Does Access to Medical Cannabis Reduce Risk for Opioid Abuse?
- Examining Rates of Long-term Opioid Use in Youth With Psychiatric Disorders
- Mortality Rates for Substance Use Disorders, Intentional Injuries Vary Widely By Country
- Facial Emotion Recognition Differentiates Behavioral Variant Frontotemporal Dementia From MDD
- The Challenge of Helping Uninsured Patients While Protecting Practice Finances
- Antidepressants Increase Seizure Risk in Youth and Severely Depressed