XYNTHA SOLOFUSE Rx
Generic Name and Formulations:
Antihemophilic Factor (recombinant): nominally 250 IU, 500 IU, 1000 IU, 2000 IU, or 3000 IU; per prefilled dual-chamber syringe; lyophilized pwd for IV inj after reconstitution; plasma/ albumin-free; preservative-free; contains polysorbate 80.
Indications for XYNTHA SOLOFUSE:
In Hemophilia A: to control and prevent bleeding episodes, and for perioperative management.
Adults and Children:
Individualize and titrate. Give by IV infusion over several minutes. One IU of factor VIII per kg raises the plasma factor VIII activity by about 2 IU/dL. Bleeding (Minor): factor VIII level required is 20–40 IU/dL or % of normal, repeat infusion every 12–24 hours as needed for at least 1 day, until resolution; (Moderate): 30–60 IU/dL or % of normal; repeat infusion every 12–24 hours for 3–4 days or until hemostasis; (Major): 60–100 IU/dL or % of normal, repeat infusion every 8–24 hours until resolution. Perioperative (Minor): 30–60 IU/dL or % of normal, repeat infusion every 12–24 hours for 3–4 days or until hemostasis; (Major): 60–100 IU/dL or % of normal; repeat infusion every 8–24 hours until hemostasis and wound healing occurs.
Hypersensitivity to hamster proteins.
Discontinue if hypersensitivity reactions occur. Monitor for development of Factor VIII inhibitors; may need dose adjustment. Pregnancy (Cat.C). Labor & delivery. Nursing mothers.
Headache, arthralgia, pyrexia, cough, diarrhea, vomiting, nausea, asthenia; anaphylaxis.
Kit—1 (w. diluent, supplies)
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Age of Onset of Bipolar Disorder Linked With Substance Use Disorders
- Mind-Body Therapy and Psychiatry: Ancient Tools for Modern Practice
- Marijuana Use Associated With Poorer Depression Outcomes, Increased Suicidal Ideation
- Low Testosterone Linked With Social Anxiety in Boys With Klinefelter Syndrome
- Atypical Symptom Presentations in Pediatric OCD
- The Psychology of Hoarding Disorder: Approaches for Treatment
- Smartphone Applications for Depression and Anxiety: Are They Ready for Widespread Use?
- The Many Misconceptions of Catatonia: Treatment Is Often Successful With the Right Knowledge
- Digital Media Engagement Associated With ADHD Symptoms in Adolescents
- Strong Social Networks May Mitigate the Effects of Childhood Adversity
- Light Therapy Effective for Older Adults with Nonseasonal Depression
- AMA Adopts Policy on Augmented Intelligence
- Parental Belief in Religion Lowers Child Suicide Risk
- Appetitive Symptoms, Fluoxetine, and Light Therapy: Predicting Treatment Response for Nonseasonal Major Depression
- Bipolar Disorder Patients Benefit From Coping Strategies for Amplified Emotionality