Generic Name and Formulations:
Mechlorethamine 0.016%; topical gel; contains propylene glycol, isopropyl alcohol.
Indications for VALCHLOR:
Treatment of Stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma in patients who have received prior skin-directed therapy.
Apply a thin film once daily to affected areas of the skin. Apply to completely dry skin ≥4 hours before or 30 minutes after showering or washing. Allow treated areas to completely dry for 5–10 minutes after applying. Wash hands thoroughly after application. Discontinue if any grade of skin ulceration, blistering, or moderately-to-severe, or severe dermatitis occur; restart at reduced frequency of once every 3 days upon improvement; if reintroduction is tolerated for at least 1 week, can increase to every other day for 1 week and then once daily if tolerated.
Mucosal (oral, nasal) or eye exposure; blindness and severe irreversible anterior eye injury may occur; immediately irrigate for ≥15 minutes with copious amounts of water. Secondary exposure; avoid direct skin contact with patient. Risk of dermatitis (eg, face, genitalia, anus, and intertriginous skin); monitor for redness, swelling, inflammation, itchiness, blisters, ulceration, and secondary skin infections. Monitor for nonmelanoma skin cancer during and after treatment. Flammable (avoid fire and flame until gel has dried). Pregnancy (Cat.D); may cause fetal harm. Nursing mothers: not recommended.
Dermatitis, pruritus, bacterial skin infection, skin ulceration or blistering, hyperpigmentation.
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Suicide Attempts Associated With Sleep and Circadian Rhythm Disturbances in Bipolar Disorder
- Anatomical Patterns Present in Childhood ADHD May Predict Phenotypic Variation
- History of ADHD Associated With Increased Risk for Basal Ganglia and Cerebellum Disorders
- Probiotics, Depression, and the Role of Inflammation
- Psychotropic Medications May Improve Pregnancy Outcomes in Bipolar Disorder
- The Opioid System: The Foundation for Social Risk and Reward
- Correctional Psychiatry: Challenges and Rewards
- Those Left Behind: Working With Suicide-Bereaved Families
- The Impact of Deafness on Hallucinations and Delusions
- Is Mandatory Reporting of Child Maltreatment in the Best Interests of the Child?
- Institutional Rearing Associated With Psychopathology Risk in Children
- Perinatal Mood and Anxiety Screening: Recommendations and Controversies
- Few Seniors Who Self-Harm Referred for Mental Health Care
- Violent Video Games Tied to Physical Aggression
- Vortioxetine Beats Escitalopram in Improving SSRI-Induced Sexual Dysfunction