ADHD Treatments







ADHD TREATMENTS
Generic Brand Form Strength Max Dose Administration
amphetamine Adzenys ER CII ext-rel oral susp 1.25mg/mL 6-12yrs: 18.8mg (15mL) daily 

13–17yrs:
12.5mg (10mL) daily

• Give once daily in the AM

• May increase by 3.1mg (2.5mL) or 6.3mg (5mL) at weekly intervals

Adzenys XR-ODT CII ext-rel orally disintegrating tabs 3.1mg, 6.3mg, 9.4mg, 12.5mg, 15.7mg, 18.8mg 6–12yrs: 18.8mg/day
13–17yrs: 12.5mg/day

• Give once daily in the AM

• May increase by 3.1mg or 6.3mg at weekly intervals

Dyanavel XR CII ext-rel oral susp 2.5mg/mL ≥6yrs: max 20mg/day

• Give once daily in the AM

• May increase by 2.5–10mg/day every 4–7 days

amphetamine sulfate Evekeo CII tabs 5mg, 10mg 3–5yrs: initially 2.5mg daily, may increase by 2.5mg/day at weekly intervals
≥6yrs: max 40mg/day

• Avoid late evening doses

• Give first dose upon awakening and additional doses at 4−6hr intervals

atomoxetine HCl Strattera Rx caps 10mg, 18mg, 25mg, 40mg, 60mg, 80mg, 100mg 1.4mg/kg or 100mg/
day (which
ever is less)

• Swallow whole

• Give once daily in the AM or in 2 divided doses (in AM + the late afternoon/
early PM)

• May discontinue without tapering dose

clonidine HCl Kapvay Rx ext-rel tabs 0.1mg, 0.2mg 0.2mg twice daily

• Swallow whole

• Titrate by response

• Withdraw gradually by 0.1mg/day at 3−7 day intervals

dextro
amphetamine sulfate
CII scored tabs 5mg, 10mg usually 40mg/day in 2−3 divided doses

• Give in the AM and then 1−2 more doses 4−6hrs apart

Dexedrine Spansule CII sust-rel caps 5mg, 10mg, 15mg usually 40mg/day

• Avoid late evening doses

Zenzedi CII tabs 2.5mg, 5mg, 7.5mg, 10mg, 15mg, 20mg, 30mg ≥3yrs: usually 40mg/day in 2–3 divided doses

• Give first dose upon awakening and then 1–2 more doses 4–6hrs apart

• Avoid late evening doses

dexmethyl
phenidate HCl
Focalin CII tabs 2.5mg, 5mg, 10mg ≥6yrs: 20mg/day

• Give twice daily at least 4hrs apart

• Single isomer methylphenidate product (use 1/2 of racemic methylphenidate dose initially)

Focalin XR CII ext-rel caps 5mg, 10mg, 15mg, 20mg, 25mg, 30mg, 35mg, 40mg 6–17yrs: 30mg/day
≥18yrs: 40mg/day

• Give once daily in the AM

• May sprinkle contents on applesauce and swallow without chewing beads

guanfacine Intuniv Rx ext-rel tabs 1mg, 2mg, 3mg, 4mg  6–12yrs: 4mg/day

13–17yrs: 7mg/day

• Swallow whole with water, milk, or other liquid

• Do not give with high‑fat meals

• Withdraw gradually by 1mg every 3−7days

lisdexam
fetamine dimesylate
Vyvanse CII caps,
chew tabs
10mg, 20mg, 30mg, 40mg, 50mg, 60mg, 70mg (caps only) ≥6yrs: 70mg/day

• Give once daily in the AM. Do not subdivide a single dose.

• Caps: swallow whole or may open and mix/dissolve contents in yogurt, water, or orange juice; take immediately

• Chew tabs: chew thoroughly before swallowing

metham
phetamine HCl
Desoxyn CII tabs 5mg ≥6yrs: usually 20−25mg daily in two divided doses

• Give once or twice daily 30min before meals

• May increase at weekly intervals

methylphen
idate
Cotempla XR-ODT CII ext-rel orally disintegrating tabs 8.6mg, 17.3mg, 25.9mg 6–17yrs: 51.8mg/day

• Give once daily in the AM

• Place on tongue and allow to disintegrate

• May titrate in increments of 8.6–17.3mg weekly

Daytrana CII trans
dermal patches
10mg, 15mg, 20mg, 30mg

• Apply patch to hip 2hrs before desired effect, remove 9hrs after application; may remove
earlier if shorter duration of effect or late day side effect appears

• May titrate dose at 1wk intervals

methylphen
idate HCl
CII tabs 5mg 60mg/day in divided doses

• Give preferably 30−45min before meals

ext-rel tabs 10mg, 20mg
scored tabs 10mg, 20mg
Concerta CII ext-rel tabs (with immediate-release outer coating) 18mg, 27mg, 36mg, 54mg  6−12yrs: 54mg/day
13−17yrs: 72mg/day or 2mg/kg/day (whichever is less)

≥18yrs: 72mg/day

• Give once daily in the AM

Jornay PM CII ext-rel caps 20mg, 40mg, 60mg, 80mg, 100mg ≥6yrs: 100mg/day

• Give once daily in the PM (between 6:30–9:30)

• May titrate in 20mg increments weekly

• May sprinkle contents on applesauce and swallow without chewing beads

Metadate CD CII ext-rel caps (containing immediate 
and ext‑rel beads)
10mg, 20mg, 30mg, 40mg, 50mg, 60mg 60mg/day

• Give once daily in the AM before breakfast

• May sprinkle contents on applesauce and swallow without chewing beads

Metadate ER CII ext-rel tabs 20mg 60mg/day in divided 
doses

• May use Metadate ER when its 8‑hr dose corresponds to the 8‑hr immediate-release dose

Methylin Chewable CII chew tabs 2.5mg, 5mg, 10mg 60mg/day in divided doses

• Give before breakfast and lunch

Methylin Oral Solution CII oral soln 5mg/
 
5mL, 10mg/
 
5mL
60mg/day in divided doses

• Give preferably 30−45min before meals

Quillichew ER CII ext-rel chew tabs 20mg, 30mg, 40mg 60mg/day

• Give once daily in the AM

• May titrate in increments of 10mg, 15mg, or 20mg

Quillivant XR CII ext-rel oral susp 25mg/
 
5mL
60mg/day

• Give once daily in the AM

• Shake bottle vigorously for ≥10sec before use

Ritalin CII tabs 5mg ≥6yrs: 60mg/day

• Give before breakfast and lunch

scored tabs 10mg, 20mg  
Ritalin LA CII ext-rel caps (half as immediate-release, half as e‑c delayed-release beads) 10mg, 20mg, 30mg, 40mg ≥6yrs: 60mg/day

• Give once daily in the AM

• May sprinkle contents on applesauce and swallow without chewing beads

mixed dextro
amphetamine/

amphetamine salts
CII double-scored tabs 5mg, 7.5mg, 10mg, 
12.5mg, 15mg, 20mg, 30mg
usually 40mg/day in 2−3 divided doses

• Give in AM and 4−6hrs apart

Adderall XR CII ext-rel caps 5mg, 10mg, 15mg, 20mg, 25mg, 30mg 30mg/day

• Give once daily in the AM

• May sprinkle contents on applesauce and swallow without chewing beads

Mydayis CII ext-rel caps 12.5mg, 25mg, 37.5mg, 50mg 13–17yrs: 25mg/day
18–55yrs: 50mg/day

• Give once daily in the AM

• May increase by 12.5mg at weekly intervals

• May sprinkle contents on applesauce and swallow without chewing beads

NOTES

Not an inclusive list of medications, official indications, or dosing
information. Please see drug monograph at www.eMPR.com
and/or contact company for full drug labeling. Use lowest effective dose. Avoid late evening
doses. Re‑evaluate periodically; improvement may be sustained when the drug is either
temporarily or permanently discontinued. If paradoxical aggravation of symptoms or other
adverse effects occur, the dose should be reduced or discontinued.

(Rev. 7/2019)

This article originally appeared on MPR