Hallucinations May Be Charles Bonnet Syndrome, Not Early Dementia
In a 10-year follow-up of AREDS 2 participants, symptoms of CBS were associated with late AMD and cataract surgery, but normal cognition.
Psychosis
Sustained Response to Pimavanserin Reduces Relapse Risk in Patients With Dementia-Related Psychosis
Can the continuation of pimavanserin help with managing dementia-related psychosis? Researchers report on the findings of the phase 3 HARMONY trial.
PsyMetRiC: a Metabolic Risk Calculator for Young Patients With Psychosis
Individuals with psychotic disorders have a 10 to 15 year shorter life span compared with the general population, mostly due to physical conditions like obesity, cardiovascular disease, and type 2 diabetes. A cardiometabolic risk prediction algorithm can offer informed treatment decisions in order to prevent long-term cardiometabolic outcomes.
Factors ID’d for Pediatric Involuntary Psychiatric Hospitalization
Children and adolescents with involuntary psychiatric hospitalization are more likely to have a diagnosis of psychosis, substance misuse, or intellectual disability than those admitted voluntarily.
Dementia-Related Psychosis and Off-Label Use of Atypical Antipsychotics
With atypical antipsychotics (AAPs) being prescribed off-label for treating dementia-related psychosis, the study authors evaluated the comparative efficacy, safety, and effectiveness of AAPS by conducting a network meta-analysis.
Antipsychotics Plus Lithium Reduced Hospital Stay for Bipolar Manic Episodes
In this study, patients were assessed for hospital stay on the basis of treatment regimen.
Digitally Supported Reasoning Intervention Improved Well-Being, Quality of Life and Paranoia Among Patients With Psychosis
In this study, the effects on paranoia and mechanisms of action of SlowMo, a digitally supported reasoning intervention, plus usual care compared with usual care only were investigated.
Cognitive Deficits in Childhood Tied to Later Mental Health Disorders
Specific cognitive deficits in childhood are distinctively associated with different mental health disorders, like borderline personality disorder, depression, and psychosis, in teens and young adults.
FDA Rejects Pimavanserin sNDA for Dementia-Related Psychosis
The sNDA submission was supported by data from the pivotal phase 3 HARMONY study.
Xanomeline-Trospium Bests Placebo in Decreasing PANSS Total Score
The goal for this phase 2 trial was to assess the efficacy and safety of the combination oral agent xanomeline-trospium in patients with acute exacerbations of schizophrenia.
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