Migraine With Active Headache Associated With Worsening of Painful Physical Symptoms in Major Depressive Disorder
Migraine with active headache may predict other painful physical symptoms in patients with major depressive disorder.
Depressive Disorder
Childhood Trauma Linked to Abnormal Brain Connectivity in Major Depressive Disorder
Childhood trauma is linked to resting state network connectivity abnormalities that may serve as an effective diagnostic biomarker.
Exercise Beneficial for Late-Life Major Depressive Disorder
Exercise is effective at reducing depressive symptoms in older adults, although antidepressants may show a faster therapeutic response.
Physical Disease, Inflammation Linked to Suicide Risk in Depression
The risk for suicide attempt is 14.9-fold greater for patients with 3 physical diseases compared with individuals with no physical diseases.
Vigorous Exercise Reduces Depression in Women With Chronic Illness
Investigators sought to determine the effect of physical activity on depression symptom severity in women age ≥45 years with a chronic illness diagnosis.
Fremanezumab Beneficial in Patients With Chronic Migraine and Moderate to Severe Depression
Investigators sought to determine the long-term safety and efficacy of fremanezumab in patients with chronic migraine and comorbid moderate to severe depression.
Age, Hypomanic Symptoms May Predict Response to Next-Step Treatment for Depression
If replicated, preliminary findings could help clinicians determine whether patients who require next-step treatment will benefit most from a switching, augmentation, or combination strategy.
Unmet Mental Health Needs in Pregnant Women With Major Depressive Episode
Findings further increase concerns about the continuing lack of mental health treatment use, particularly given the recent policy focus on perinatal depression.
Polygenic Risk Scores May Predict Depression Outcomes in Youth
Depression polygenic risk score may support the identification of youths at risk for major depression before the emergence of clinically significant symptoms.
Modest Clinician Support Enhances Computer-Assisted Cognitive Behavioral Therapy
Telephone or face-to-face support had a significantly larger effect in conjunction with computer-assisted cognitive behavioral therapy than online asynchronous support.
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