Lumateperone sNDAs Submitted for Bipolar Depression Indication
The sNDA submissions are supported by data from 2 global randomized, double-blind, placebo-controlled phase 3 studies.
Bipolar Disorders
LEF1 Gene a Possible Target for Bipolar Disorder Drug Development
While treatment for mood stabilization in bipolar disorder is most commonly lithium, all patients do not respond to such treatment. The authors of this study investigated what causes lithium resistance.
Psychotropic Drug Indications
A comparative list of psychotropic medications with their mood disorder indications (bipolar disorder, major depressive disorder, treatment resistant depression, premenstrual dysphoric disorder, and others).
Patients With Both Dementia and Severe Mental Illness Experience Faster Cognitive Decline
Researchers analyzed data from the population of 4 South London boroughs to determine the impact of comorbid bipolar disorder and schizophrenia on the cognitive decline in dementia.
Receipt of Disability Services Elevated in Individuals With Mood Disorders
Investigators looked into the risks of receiving disability services after a first diagnosis of mood or common mental disorder.
Mental Illness Recognition Up in UK General Hospital Admissions
From 2006 to 2017, there was improvement in the sensitivity for recording of severe mental illness diagnosis in English general hospitals.
Understanding the Underlying Neurobiology Behind Group Differences in Cortical Thickness Across Psychiatric Disorders
This study highlights the importance of transdiagnostic approaches to psychiatry.
Stimulants May Reduce Self-Injury in Patients with Bipolar Disorder and Comorbid ADHD
Researchers conducted a retrospective study to assess self-injury behavior in patients with bipolar disorder and comorbid ADHD after initiation of a central stimulant.
Atypical Antipsychotics May Dysregulate Immune Response, Increase Risk for COVID-19
Short- to intermediate-term exposure to atypical antipsychotic medications may dysregulate adaptive immune responses, increasing susceptibility to respiratory infections like COVID-19.
No Increase in Treatment-Emergent Mania With Lurasidone for Bipolar Depression
Researchers assessed data from short-term studies with open-label extensions among adults and adolescents with bipolar depression to assess the impact of lurasidone on treatment-emergent mania.
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