Heterogeneity in Alzheimer Disease Progression Affects Clinical Trial Results
Investigators assessed the variability in effect of treatment over time among patients with mild cognitive impairment or dementia.
Alzheimer Disease
Donanemab Granted Breakthrough Tx Status for Alzheimer Disease
Donanemab is an investigational antibody therapy that targets a modified form of deposited amyloid-β peptide called N3pG.
Novel, Rare Variants Associated With Alzheimer Disease and Replicated in an Independent Cohort
The study researchers used deep whole-genome sequencing (WGS) to search for novel AD variants in 2247 individuals from 605 multiplex AD families from the National Institute on Mental Health and the National Institute on Aging (NIA) Alzheimer’s Disease Sequencing Project `data sets.
History of Depression, Anxiety Inversely Correlates With Age of Onset in Alzheimer Disease
There may be an association between a history of psychiatric disorders in patients and age of onset of Alzheimer disease.
Patients With Alzheimer Disease Have Accelerated Asymmetrical Thinning of Brain Cortex Regions
Looking at the cross-sectional studies assessing age effects upon cortical thickness asymmetry, results have been inconsistent. The study authors investigated whether and where cerebral hemispheres thin at different rates.
Variants of Apolipoprotein E May Be Novel Biomarkers for Late-Onset Alzheimer Disease
Despite the many loci associated with late-onset Alzheimer disease, researchers are still short of a robust, unified method of risk stratification based on genome variations due to the clinical heterogeneity and polygenic nature of the disease.
Anosognosia May Serve as an Early Indicator of Alzheimer Disease
This study looks at how the lack of awareness (anosognosia) of memory impairment evolves in the trajectory of Alzheimer disease.
Vaccination Linked to Reduced Alzheimer Disease Risk
At AAIC 2020, 2 presentations separately discussed observing a reduced risk of AD in patients who received the influenza and pneumonia vaccines.
Antiepileptic Drugs May Up Death Risk in Patients With Alzheimer Disease
Antiepileptic drugs are associated with a higher risk for mortality in patients with Alzheimer disease.
First Diagnostic Agent Approved to Image Tau Pathology in Patients Being Evaluated for Alzheimer Disease
Tauvid is indicated for use with positron emission tomography (PET) imaging of the brain.
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