NeuroRx announced that the FDA has granted Breakthrough Therapy designation to NRX-101 for the treatment of severe bipolar depression with acute suicidal ideation.
Patients with bipolar disorder face a risk for suicide that is up to 20 times greater than that of the general population. However, the specific factors that contribute to this risk are not necessarily comparable across all populations.
Suicide rates have increased significantly in the US since 1999.
Children who were described as both highly depressed/anxious and highly irritable were 2 times as likely to report suicidal thinking and attempts compared with children who exhibited neither depression nor irritability.
Investigators sought to identify distinct pathways toward suicidal behaviors in older adults with major depression.
Suicidal thinking may influence affect in a reinforcing manner, partially explaining its persistent nature in subsets of patients.
Adolescents have an increased risk of suicide after nonfatal self-harm.
These results indicate the need for thorough preoperative psychiatric history assessment in patients considering bariatric surgery, as well as postoperative surveillance.
Suicide in prisons is multifactorial, with contributing factors that include medical and mental health issues as well as those involving family, lack of purposeful activity, and conditions of the specific prison environment, as well as the stress of adjusting to incarceration.
Dermatologic diseases such as acne, psoriasis and atopic dermatitis frequently have psychiatric comorbidities such as depression or suicidal ideation.
There was a drop in PTSD symptoms with hyperbaric oxygen therapy.
Mixed state does not increase the risk for suicidal behavior beyond the risk associated with the depressive component.
Suicidal ideation in patients is often missed by psychiatrists who use questions biased toward confirming patients are not suicidal.
Emergency departments may reduce subsequent suicide attempts and risk, according to multiple university studies.
Well-intentioned parents may not realize that it is terrifying for a youngster to be left without any parental direction, even if the child does not act scared.
Self-injury treatment strategies can be challenging because some patients are ambivalent about receiving help.
In a new study, teens and young adults with bipolar disorder who had attempted suicide had slightly less volume and activity in areas of the brain that regulate emotion and impulses.
Clinicians need to be aware of the potential risks when they prescribe antidepressants and other drugs used in the treatment of depression.
Effort must be made to create a more supportive medical education environment.
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