'Depressive Mixed States' Often Precede Suicide Attempts
the Psychiatry Advisor take:
“Depressive mixed states,” where a patient is depressed, but also has symptoms of mania, is one of several bevavior patterns identified that often precedes suicide attempts, a discovery that may help clinicians treating depressed patients.
Dina Popovic, MD, PhD, of the Hospital Clinic of Barcelona, Spain, and colleagues, conducted the BRIDGE-II-MIX study, which included 2,811 depressed patients, 628 of whom had attempted suicide. The patients were interviewed by psychiatrists, with an eye toward the characteristics and behaviors of those who had attempted suicide.
Forty percent of depressed patients that attempted suicide had a mixed episode, and not just depression, the researchers found. Also, patients who exhibit mixed depressive episodes are at a significantly higher risk of suicide.
Further analysis of the interviews found that risky behavior, psychomotor agitation and impulsivity in a depressed patients increases their risk of attempting suicide by at least 50%.
“Most of these symptoms will not be spontaneously referred by the patient, the clinician needs to inquire directly, and many clinicians may not be aware of the importance of looking at these symptoms before deciding to treat depressed patients,” Popovic said in a statement.
Study finds that 40% of depressed patients who attempted suicide had a mixed episode.
A major multi-national study of suicides has identified the behavior patterns which precede many suicide attempts. This may lead to changes in clinical practice in the care of patients affected with depression, as it shows the clinical factors which confer major risk of suicide attempts.
The statistics for suicide are frightening. According to the WHO, more than 800,000 people commit suicide every year, with perhaps 20 times that number attempting suicide. Suicide is one of the leading causes of death in the young (in the UK for example, it is the leading cause of death in men under 35) see notes, below. Effective measures of suicide prevention are urgently needed.
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Adjunctive Therapies for Bipolar Disorder Show Promise, Need More Evidence
- Predicting Treatment-Emergent Mania to Tailor Pharmacotherapy in Bipolar Disorder
- Antidepressants Increase Seizure Risk in Youth and Severely Depressed
- Abnormalities of Cortical Thickness in Bipolar Disorder With Auditory Hallucinations
- Prevalence of Major Depressive Disorder Remains High In US Population
- The Way to the Head May Be Through the Gut: Probiotics for Depression
- Suicide-Screening Toolkit Can Help Identify Youths at High Risk for Suicide
- Agoraphobia: An Evolving Understanding of Definitions and Treatment
- Parental Pressure to Diet Linked With Long-term Harm in Adolescents
- Does Access to Medical Cannabis Reduce Risk for Opioid Abuse?
- Suicide Risk After Self-Harm Among Adolescents, Young Adults
- E-Cigarettes Associated With More Harms Than Benefits at Population Level
- Safety, Efficacy of Deep Brain Stimulation for Alzheimer's
- Many Teens Who Use Tobacco Don't Self-Identify as Users
- Evidence of Methylphenidate Abuse: Characterizing Patterns of Use in Pediatric and Adult Populations