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LabMed

Monocytosis

At a Glance Monocytosis is defined as an absolute monocyte count greater than 2SD above the mean for the patient population. Typically, this represents a monocyte count greater than 800 per microliter in adults. Monocyte counts may be significantly higher in children (e.g., up to 3000 per microliter), and age-specific normals should be used to…
Pediatrics

Diagnosis and Management of Transient Hypogammaglobulinemia of Infancy

OVERVIEW: What every practitioner needs to know Are you sure your patient has transient hypogammaglobulinemia of infancy? What are the typical findings for this disease? Transient hypogammaglobulinemia of infancy (THI) is a relatively common primary immunodeficiency disease that affects infants and young children. THI is characterized by decreased serum immunoglobulin (Ig)G levels with or without…
Oncology

Castleman's disease

Castleman's disease What every physician needs to know: Introduction Castleman’s disease (CD) is a rare, nonclonal lymphoproliferative disorder. It affects a single lymph node region (unicentric) or may affect multiple lymph node areas including hepatosplenomegaly (multicentric). Although precise incidence of CD in the United States of America (USA) is unknown, only a few hundred cases…
Hematology

Castleman's disease

Castleman's disease What every physician needs to know: Introduction Castleman’s disease (CD) is a rare, nonclonal lymphoproliferative disorder. It affects a single lymph node region (unicentric) or may affect multiple lymph node areas including hepatosplenomegaly (multicentric). Although precise incidence of CD in the United States of America (USA) is unknown, only a few hundred cases…
Hematology

Leukocytosis

Leukocytosis What every physician needs to know about leukocytosis: The peripheral white blood cell count (WBC) ranges from 5.0 to 10.0 x 109/L. Leukocytosis is defined as a white count above 11.0 x 109/L. Because circulating white cells include heterogeneous cell types (neutrophils [Figure 1], monocytes [Figure 2], basophils, eosinophils [Figure 3], and a variety…
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