Schizophrenia

First-Episode Drug-Naive Patients With Schizophrenia More Likely to Attempt Suicide

First-Episode Drug-Naive Patients With Schizophrenia More Likely to Attempt Suicide

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Researchers found a suicide attempt rate of 12.0% in first-episode, drug-naïve inpatients.

Second Generation Long-Acting Injectable Drugs Effective for Schizophrenia

Second Generation Long-Acting Injectable Drugs Effective for Schizophrenia

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The findings support second generation long-acting injectable antipsychotic drug use as early treatment option to increase treatment adherence and to decrease the risk of relapse, hospitalization, and deteriorating social functions.

Potential Utility of Adjunctive <i>Withania somnifera</i> in Schizophrenia Treatment

Potential Utility of Adjunctive Withania somnifera in Schizophrenia Treatment

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WSE treatment may be useful in addressing symptom exacerbation in schizophrenia and schizoaffective disorder.

Social Functioning, Treatment With Antipsychotic Agents Associated With Employment in Schizophrenia

Social Functioning, Treatment With Antipsychotic Agents Associated With Employment in Schizophrenia

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Investigators examined factors that may improve employment in patients with schizophrenia.

Once-Monthly Perseris Approved for the Treatment of Schizophrenia

Once-Monthly Perseris Approved for the Treatment of Schizophrenia

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Perseris, an atypical antipsychotic, has an extended-release delivery system that releases sustained levels of risperidone over 1 month.

Antipsychotic Medication May Affect HDL-Cholesterol Levels for Some Patients With Schizophrenia

Antipsychotic Medication May Affect HDL-Cholesterol Levels for Some Patients With Schizophrenia

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These results may be helpful for clinicians when considering the effects of antipsychotic intervention on patient high-density lipoprotein cholesterol levels.

Adolescent Inhalant Use Associated With Higher Risk for Psychosis

Adolescent Inhalant Use Associated With Higher Risk for Psychosis

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Inhalant and other substance use during adolescence are increasingly associated with many adverse health and psychosocial outcomes.

Early Interventions Effective in Reducing Psychosis Duration in Military Personnel

Early Interventions Effective in Reducing Psychosis Duration in Military Personnel

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These data have implications for the efficacy of the US military healthcare system as a whole in treating psychosis in service members.

FDA Approval of Medication With a Digital Monitoring System: Major Breakthrough or "Brave New World"?

FDA Approval of Medication With a Digital Monitoring System: Major Breakthrough or "Brave New World"?

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Abilify MyCite adds a digital sensor to the medication aripiprazole. The sensor, an ingestible event marker, is activated by contact with stomach acids and transmits a signal to a skin patch the patient wears, which then transmits to an app.

Long-Acting Injectables Effective in Patients With Comorbid Psychosis, Substance Use Disorder

Long-Acting Injectables Effective in Patients With Comorbid Psychosis, Substance Use Disorder

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As psychosis and substance use disorder comorbidity can make oral medication adherence difficult, long-acting injectable agents may be an effective therapeutic alternative in patients in this demographic.

Classification Models for Diagnosing Schizophrenia With MRI Neuroimaging

Classification Models for Diagnosing Schizophrenia With MRI Neuroimaging

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Each of the studied brain modalities could be classified as "gray matter abnormalities" or "white matter disruptions" and may be significant in the pathology of schizophrenia.

Brain Age Differences From Chronological Age Can Predict Early-Onset Psychosis in Adolescents

Brain Age Differences From Chronological Age Can Predict Early-Onset Psychosis in Adolescents

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This study created a validated model for determining brain age and brain age gap, which then can be used to predict early-onset psychosis in younger clinically high-risk adolescents who exhibit prodromal symptoms.

Distinct Characteristics in Children at Risk for Schizophrenia vs Bipolar Disorder

Distinct Characteristics in Children at Risk for Schizophrenia vs Bipolar Disorder

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The findings of this study contribute to the understanding of the neurodevelopmental cognitive vulnerability in middle childhood for the children of people with either schizophrenia or bipolar disorder.

Adjunctive Aripiprazole Lowers Prolactin Levels in Women With Psychosis

Adjunctive Aripiprazole Lowers Prolactin Levels in Women With Psychosis

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These data suggest that aripiprazole can be safely used in premenopausal women to treat elevated prolactin levels and prolactin-related adverse effects.

Atypical Antipsychotic Use and CV Events in Youth: What's the Link?

Atypical Antipsychotic Use and CV Events in Youth: What's the Link?

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Atypical antipsychotic use was associated with a higher risk for cardiovascular events among publicly insured youth in the US.

Aristada Initio Regimen Approved for Initiation of Schizophrenia Treatment

Aristada Initio Regimen Approved for Initiation of Schizophrenia Treatment

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Prior to this approval, the Aristada initiation regimen consisted of taking oral aripiprazole for 21 consecutive days starting with the first Aristada dose.

Treatment Implications for Varying Depressive Symptoms in Acute Psychosis

Treatment Implications for Varying Depressive Symptoms in Acute Psychosis

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The main message from the present paper is to carefully identify the psychotic patients that do not improve from their debilitating depressive symptoms during an acute phase of psychosis.

Efficacy of Long-Acting Injectable Antipsychotics vs Oral Antipsychotics

Efficacy of Long-Acting Injectable Antipsychotics vs Oral Antipsychotics

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Results of this meta-analysis highlight the potential advantages of long-acting injectable antipsychotics vs oral antipsychotics in treating schizophrenia.

Medication Adherence Predictors in Patients With Severe Psychiatric Disorders

Medication Adherence Predictors in Patients With Severe Psychiatric Disorders

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As antipsychotic medications are vital to the effective management of severe psychiatric disorders, investigators sought to examine reasons for medication nonadherence in patients with schizophrenia, bipolar disorders, and other psychotic disorders.

Comorbid OCD Confers Greater Neurocognitive Impairment in Schizophrenia

Comorbid OCD Confers Greater Neurocognitive Impairment in Schizophrenia

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In considering patients with schizophrenia for cognitive remediation, comorbid OCD must be taken into account.

Visual Integration Impairment Characteristic of Psychosis, Not Specific to Schizophrenia

Visual Integration Impairment Characteristic of Psychosis, Not Specific to Schizophrenia

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These results indicate that impaired visual integration in patients with schizophrenia may more broadly be a feature of psychosis, rather than specifically of schizophrenia.

Efficacy of MIN-101 in Treating Negative Symptoms of Schizophrenia

Efficacy of MIN-101 in Treating Negative Symptoms of Schizophrenia

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Researchers hope that in demonstrating the potential efficacy of MIN-101, they may improve the pharmacotherapy options available to patients with schizophrenia.

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

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A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.

Early Intervention Services Superior to Treatment as Usual for Early-Phase Psychosis

Early Intervention Services Superior to Treatment as Usual for Early-Phase Psychosis

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The superior benefit provided by early intervention services for schizophrenia could be cost-effective, and the researchers call for widespread implementation and funding of early intervention services in the United States and globally.

Risk of Breast Cancer May Be Higher in Women With Schizophrenia

Risk of Breast Cancer May Be Higher in Women With Schizophrenia

Researchers conducted a systematic literature review to identify cohort studies reporting the standardized incidence ratio for the risk of breast cancer in women with schizophrenia compared with the general population.

Deutetrabenazine Associated With Long-Term Improvements for Tardive Dyskinesia

Deutetrabenazine Associated With Long-Term Improvements for Tardive Dyskinesia

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Investigators examined the long-term efficacy of deutetrabenazine measured by Abnormal Involuntary Movement Scale, Clinical Global Impressions Scale, and Patients' Global Impression of Change Scale in real-word clinical practice settings.

Adjunctive Raloxifene vs Antipsychotics Alone for Schizophrenia, Schizoaffective Disorder

Adjunctive Raloxifene vs Antipsychotics Alone for Schizophrenia, Schizoaffective Disorder

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Adjunctive raloxifene may reduce negative symptom scores in women with schizophrenia or schizoaffective disorder.

Antipsychotic Efficacy, Safety of ALKS 3831 Evaluated for Acute Schizophrenia

Antipsychotic Efficacy, Safety of ALKS 3831 Evaluated for Acute Schizophrenia

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The phase 3 study assessed the antipsychotic efficacy and safety of ALKS 3831 in patients with acute exacerbations of schizophrenia.

Substance Use Disorders Associated With Conversion From Schizotypal Disorder to Schizophrenia

Substance Use Disorders Associated With Conversion From Schizotypal Disorder to Schizophrenia

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These data may be helpful in titrating care for those with schizotypal disorder and comorbid substance abuse disorders to mitigate the risk for conversion to schizophrenia.

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

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Concerns over Nuplazid were initially voiced in a CNN article in early April which reported that the drug had been associated with over 700 deaths since its launch in March 2017.

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