Schizophrenia

Efficacy of Long-Acting Injectable Antipsychotics vs Oral Antipsychotics

Efficacy of Long-Acting Injectable Antipsychotics vs Oral Antipsychotics

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Results of this meta-analysis highlight the potential advantages of long-acting injectable antipsychotics vs oral antipsychotics in treating schizophrenia.

Medication Adherence Predictors in Patients With Severe Psychiatric Disorders

Medication Adherence Predictors in Patients With Severe Psychiatric Disorders

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As antipsychotic medications are vital to the effective management of severe psychiatric disorders, investigators sought to examine reasons for medication nonadherence in patients with schizophrenia, bipolar disorders, and other psychotic disorders.

Comorbid OCD Confers Greater Neurocognitive Impairment in Schizophrenia

Comorbid OCD Confers Greater Neurocognitive Impairment in Schizophrenia

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In considering patients with schizophrenia for cognitive remediation, comorbid OCD must be taken into account.

Antipsychotic Treatment Linked to Adiposity Changes in Youth

Antipsychotic Treatment Linked to Adiposity Changes in Youth

Youth receiving antipsychotic treatment have adverse changes in adiposity and insulin sensitivity, with the greatest fat increases seen with olanzapine.

Visual Integration Impairment Characteristic of Psychosis, Not Specific to Schizophrenia

Visual Integration Impairment Characteristic of Psychosis, Not Specific to Schizophrenia

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These results indicate that impaired visual integration in patients with schizophrenia may more broadly be a feature of psychosis, rather than specifically of schizophrenia.

Efficacy of MIN-101 in Treating Negative Symptoms of Schizophrenia

Efficacy of MIN-101 in Treating Negative Symptoms of Schizophrenia

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Researchers hope that in demonstrating the potential efficacy of MIN-101, they may improve the pharmacotherapy options available to patients with schizophrenia.

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

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A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.

Early Intervention Services Superior to Treatment as Usual for Early-Phase Psychosis

Early Intervention Services Superior to Treatment as Usual for Early-Phase Psychosis

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The superior benefit provided by early intervention services for schizophrenia could be cost-effective, and the researchers call for widespread implementation and funding of early intervention services in the United States and globally.

Risk of Breast Cancer May Be Higher in Women With Schizophrenia

Risk of Breast Cancer May Be Higher in Women With Schizophrenia

Researchers conducted a systematic literature review to identify cohort studies reporting the standardized incidence ratio for the risk of breast cancer in women with schizophrenia compared with the general population.

Deutetrabenazine Associated With Long-Term Improvements for Tardive Dyskinesia

Deutetrabenazine Associated With Long-Term Improvements for Tardive Dyskinesia

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Investigators examined the long-term efficacy of deutetrabenazine measured by Abnormal Involuntary Movement Scale, Clinical Global Impressions Scale, and Patients' Global Impression of Change Scale in real-word clinical practice settings.

Adjunctive Raloxifene vs Antipsychotics Alone for Schizophrenia, Schizoaffective Disorder

Adjunctive Raloxifene vs Antipsychotics Alone for Schizophrenia, Schizoaffective Disorder

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Adjunctive raloxifene may reduce negative symptom scores in women with schizophrenia or schizoaffective disorder.

Antipsychotic Efficacy, Safety of ALKS 3831 Evaluated for Acute Schizophrenia

Antipsychotic Efficacy, Safety of ALKS 3831 Evaluated for Acute Schizophrenia

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The phase 3 study assessed the antipsychotic efficacy and safety of ALKS 3831 in patients with acute exacerbations of schizophrenia.

Substance Use Disorders Associated With Conversion From Schizotypal Disorder to Schizophrenia

Substance Use Disorders Associated With Conversion From Schizotypal Disorder to Schizophrenia

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These data may be helpful in titrating care for those with schizotypal disorder and comorbid substance abuse disorders to mitigate the risk for conversion to schizophrenia.

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

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Concerns over Nuplazid were initially voiced in a CNN article in early April which reported that the drug had been associated with over 700 deaths since its launch in March 2017.

Sleep Disturbances, Trauma Associated With Psychosis-Like Experiences

Sleep Disturbances, Trauma Associated With Psychosis-Like Experiences

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These findings may be helpful in developing treatment strategies for patients with past trauma and sleep disturbances to attenuate the possibility of future psychosis-like experiences.

Children of Consanguineous Marriage at Increased Risk for Mood Disorders, Psychoses

Children of Consanguineous Marriage at Increased Risk for Mood Disorders, Psychoses

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Communities that favor consanguineous marriage should receive sensitive advice on the risks involved to aid in reproductive decision making.

Childhood Insulin Resistance Associated With Later Psychosis

Childhood Insulin Resistance Associated With Later Psychosis

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The authors advised clinicians to carefully consider which antipsychotics they prescribe their patients with metabolic dysfunction, as some are known to be diabetogenic.

Haloperidol Associated With Slight Increased Risk for Death in Acute Myocardial Infarction

Haloperidol Associated With Slight Increased Risk for Death in Acute Myocardial Infarction

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These data may be useful to clinicians in considering the risks and benefits of prescribing haloperidol for patients with cardiac morbidity.

Violence in Schizophrenia Associated With Several Risk Factors at Diagnosis

Violence in Schizophrenia Associated With Several Risk Factors at Diagnosis

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In patients with a history of pre-diagnostic violence, a history of non-violent offending in the 18-month period pre-diagnosis was the strongest predictor of future violence.

Clinical Outcomes Assessed for Major Depressive Disorder With Psychotic Features

Clinical Outcomes Assessed for Major Depressive Disorder With Psychotic Features

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Major depressive disorder with psychotic features had comparative long-term outcomes with schizophrenia, schizoaffective disorder, and bipolar disorder.

Exploring Brain Stimulation as a Treatment for Auditory Hallucinations in Schizophrenia

Exploring Brain Stimulation as a Treatment for Auditory Hallucinations in Schizophrenia

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The authors pointed to a possible difference in the specific symptoms alleviated by different types of stimulation.

Recovery From First-Episode Psychosis More Likely in Those With Mania, Brief Psychosis Diagnoses

Recovery From First-Episode Psychosis More Likely in Those With Mania, Brief Psychosis Diagnoses

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The early sustained recovery group was more likely to have a diagnosis other than schizophrenia, particularly mania or brief psychosis.

Old Challenges and New Directions in Managing Tardive Dyskinesia

Old Challenges and New Directions in Managing Tardive Dyskinesia

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"Since the current generation of psychiatrists has been raised on second-generation antipsychotics and has relatively little experience with first-generation antipsychotics, keeping tardive dyskinesia in mind is not, on the whole, part of their experience or training," said Christoph U. Correll, MD.

Negative Symptoms Increase Cardiovascular Risk in Schizophrenia

Negative Symptoms Increase Cardiovascular Risk in Schizophrenia

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Although various clinical and psychosocial factors were associated with unhealthy lifestyle factors and higher risk for CVD, the strongest associations were with negative symptoms.

Cognitive Impairment May Predict Persistent Psychosis in Ketamine Users

Cognitive Impairment May Predict Persistent Psychosis in Ketamine Users

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Ketamine-dependent patients who exhibited psychosis demonstrated levels of spatial problem solving and verbal memory impairment similar to those of patients with schizophrenia.

Improving Performance of Everyday Activities Is Critical in Schizophrenia

Improving Performance of Everyday Activities Is Critical in Schizophrenia

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Treatment beyond antipsychotic drugs is needed for people with schizophrenia, as positive symptoms are a peripheral node in the network.

Heavy Cigarette Smoking in Adolescence May Increase Risk for Psychosis

Heavy Cigarette Smoking in Adolescence May Increase Risk for Psychosis

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Despite the recognition that early daily tobacco use likely increases the risk for later psychosis, investigation of the effect of covariates such as substance use, existing psychotic features, or parental/family factors was lacking in the literature.

CBT Plus Cognitive Remediation May Improve Vocational Outcomes in Schizophrenia

CBT Plus Cognitive Remediation May Improve Vocational Outcomes in Schizophrenia

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These results suggest that CBT alone may be insufficient in enhancing work outcomes in patients with schizophrenia, despite its efficacy in treating other symptoms.

Adjunctive Raloxifene May Improve Psychotic Symptoms in Postmenopausal Women With Schizophrenia

Adjunctive Raloxifene May Improve Psychotic Symptoms in Postmenopausal Women With Schizophrenia

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The meta-analysis showed raloxifene to be effective for positive symptoms, negative symptoms, and general psychopathology, with greatly homogeneous results.

Noninvasive Brain Stimulation May Improve Negative Schizophrenia Symptoms

Noninvasive Brain Stimulation May Improve Negative Schizophrenia Symptoms

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The findings of this meta-analysis suggested that both repetitive transcranial magnetic stimulation and transcranial direct current stimulation were significantly more effective at improving negative symptoms than sham stimulation.

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