In patients with Parkinson disease psychosis, treatment with pimavanserin has a lower risk for mortality compared with quetiapine or combination therapy.
The authors suggest that anxiety should be routinely evaluated in patients with Parkinson disease who experience freezing of gait.
As the neurodegenerative processes of Alzheimer disease and Parkinson disease are different, early cognitive impairment also present differently in these diseases.
Patients who felt the situation was "abnormal" were less likely to seek help. This trend was more common in patients with Parkinson disease than patients with dementia, although both described feeling "embarrassed or ashamed."
Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson disease psychosis.
Concerns over Nuplazid were initially voiced in a CNN article in early April which reported that the drug had been associated with over 700 deaths since its launch in March 2017.
Mild traumatic brain injury is associated with increased risk of Parkinson disease among military veterans.
A new analytic model can now predict cognitive decline within 10 years of onset PD.
More specific biomarkers will be needed to differentiate between atypical parkinsonian disorders.
Research on monogenic disorders has made vital contributions to all aspects of medical care, including our understanding of pain pathophysiology.
Levodopa pill can wear off, but a powdered version can help patients during off periods.
The study suggests that statins may serve a greater purpose beyond control of lipids and cardiovascular events.
Researchers saw a beneficial effect in tests examining frontal lobe function and improvement in memory.
Dopaminergic Control of Striatal Cholinergic Interneurons May Cause Antipsychotic-Associated ParkinsonismJuly 21, 2016
Research examines the underlying mechanisms for the disabling adverse effects associated with antipsychotic medications.
To date, there are no validated biomarkers to independently assess Parkinson Disease diagnosis and prognosis, or to measure disease severity.
If transmission of neurodegenerative diseases such as dementia of any type, AD, or PD does occur, it is rare.
Declining smoking rates could be associated with higher incidence of parkinsonism and PD.
The drug is the first of its kind to address PD psychosis without having an ill effect on motor symptoms.
Declines in processing sleep and episodic memory were observed in those with low levels of activity.
The researchers observed between-group differences between real and sham acupuncture treatment.
Unclear whether the medications or the disease are the key factor; study only shows an association.
Research found an association, but no cause-and-effect relationship, between rosacea and Parkinson's.
Those with cognitive difficulties struggle to follow conversations or recall words.
Study reports on the availability of safety and efficacy data for over-the-counter supplements for improving brain health.
Of adults aged 45 years and older reporting recent check-up, only 25.2% reported SMCs.
However, results should be interpreted with attention to the study details, Mayo doc says.
Men with higher urate concentrations had a lower future risk of developing Parkinson's, suggesting that urate could have a protective factor.
Those who took rivastigmine in study were 45% less likely to have an accident.
Results from a recent multiple sclerosis trial with simvastatin indicate that it could be an effective treatment to slow progression of Parkinson's.
There was no difference in cognition between Parkinson's patients taking a high and lower level of anticholinergic medications.
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