Pancuronium Bromide Injection Rx
Generic Name and Formulations:
Pancuronium bromide 1mg/mL, 2mg/mL; soln for IV inj; contains benzyl alcohol.
Various generic manufacturers
Indications for Pancuronium Bromide Injection:
Adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Adults and Children:
Individualize. Adjunct to anesthesia: Initially 0.04 to 0.1mg/kg, then may use incremental doses starting at 0.01mg/kg. Relaxation for intubation: inject bolus dose of 0.06 to 0.1mg/kg. Neonates: give test dose 1st of 0.02mg/kg. Monitor with a peripheral nerve stimulator to avoid overdosage.
To be administered under the supervision of experienced clinicians. Have intubation, artificial respiration, oxygen therapy and reversal agents available. Myasthenia gravis or myasthenic (Eaton-Lambert) syndrome (do test dose and monitor). Pre-existing pulmonary disease. Renal disease or failure. Hepatic and/or biliary tract disease. Cardiovascular disease and edematous state. Long-term use in I.C.U. Immobilized for long periods. Severe obesity or neuromuscular disease; monitor airway and ventilation. Electrolyte imbalance. Adrenal cortical insufficiency. Neonates. Elderly. Pregnancy (Cat.C). Nursing mothers.
Neuromuscular blocker (nondepolarizing).
Prior administration of succinylcholine may potentiate effects (delay dose or give pancuronium 1st). Potentiated by volatile inhalational anesthetics (eg, enflurane, isoflurane, halothane), aminoglycosides, tetracyclines, bacitracin, polymyxin B, colistin, sodium colistimethate, magnesium salts. Significant additive effects with pancuronium bromide-metocurine and pancuronium bromide-d-tubocurarine combinations than with the individual drugs given alone. Potential severe ventricular arrhythmias in concomitant with tricyclics and halothane. Caution with quinidine injection.
Skeletal muscle weakness or prolonged paralysis, circulatory effects, salivation, transient rash; rare: hypersensitivity reactions.
Formerly known under the brand name Pavulon.
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Age of Onset of Bipolar Disorder Linked With Substance Use Disorders
- Rapid Cycling in Bipolar Disorder: Overview and Expert Perspectives
- Low Testosterone Linked With Social Anxiety in Boys With Klinefelter Syndrome
- Posttraumatic Stress Disorder Associated With Reduced Brain Volume
- First-Episode Drug-Naive Patients With Schizophrenia More Likely to Attempt Suicide
- The Psychology of Hoarding Disorder: Approaches for Treatment
- Mind-Body Therapy and Psychiatry: Ancient Tools for Modern Practice
- Smartphone Applications for Depression and Anxiety: Are They Ready for Widespread Use?
- The Many Misconceptions of Catatonia: Treatment Is Often Successful With the Right Knowledge
- Marijuana Use Associated With Poorer Depression Outcomes, Increased Suicidal Ideation
- Significant Rates of Major Depressive Disorder Found in Dementia
- Link Between Vitamin D Levels and Intracranial Volume in Schizophrenia
- TBI Linked to Increased Suicide Risk
- Behavioral Executive Dysfunction Associated With Chronic Kidney Disease
- Factors That Predict Treatment Outcomes, Remission in Pediatric OCD