Neurocognitive

Visual Hallucinations in Dementia and Parkinson Disease: Assessment of Patient Experiences

Visual Hallucinations in Dementia and Parkinson Disease: Assessment of Patient Experiences

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Patients who felt the situation was "abnormal" were less likely to seek help. This trend was more common in patients with Parkinson disease than patients with dementia, although both described feeling "embarrassed or ashamed."

Telemedicine Intervention for Neuropsychiatric Symptoms in Long-term Care Facilities

Telemedicine Intervention for Neuropsychiatric Symptoms in Long-term Care Facilities

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Researchers of the DETECT study aim to assess the potential for future implementation of telemedicine consultation for managing neuropsychiatric symptoms in long-term care facilities.

FDA Approves New Nuplazid Formulation, Dosage Strength

FDA Approves New Nuplazid Formulation, Dosage Strength

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Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson disease psychosis.

Benzodiazepines, Related Drugs Associated With Modestly Increased Risk for Alzheimer Disease

Benzodiazepines, Related Drugs Associated With Modestly Increased Risk for Alzheimer Disease

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Given the frequent use of benzodiazepines among older people, even a small increase in absolute risk may be a serious matter on a population level.

Herpesvirus Abundant in Alzheimer Disease Brain, New Study Finds

Herpesvirus Abundant in Alzheimer Disease Brain, New Study Finds

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While hundreds of published reports have made an argument for an association between Alzheimer disease and bacteria and viruses, the suggestion of a viral contribution to Alzheimer disease has not always been well received by the greater research community.

Higher Blood Pressure at Midlife Increases Risk for Dementia

Higher Blood Pressure at Midlife Increases Risk for Dementia

The risk of dementia is increased in 50-year-olds with blood pressure ≥130 mm Hg, which is below the current threshold for hypertension.

Cognitive Performance, Mood Deficits, White Matter Hyperintensities in Migraine

Cognitive Performance, Mood Deficits, White Matter Hyperintensities in Migraine

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Carefully assessing cognitive performance using a screening test to detect visuospatial/executive, attention, and memory dysfunction in patients with migraine.

Trials for Investigational Alzheimer Treatment Lanabecestat Discontinued

Trials for Investigational Alzheimer Treatment Lanabecestat Discontinued

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Phase 3 clinical trials for lanabecestat (Eli Lilly and AstraZeneca), an investigational Alzheimer disease treatment, are being discontinued for futility.

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

The lifetime risks of Alzheimer disease dementia vary considerably by age, gender, and the preclinical or clinical disease state.

Intellectual Activities in Later Life May Cut Dementia Risk

Intellectual Activities in Later Life May Cut Dementia Risk

There is a reduced risk for dementia for older Chinese adults actively participating in intellectual activities.

Examining the Content, Frequency of Auditory Hallucinations in Dementia

Examining the Content, Frequency of Auditory Hallucinations in Dementia

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These results highlight the risk for auditory hallucinations in certain subsets of patients with dementia with Lewy bodies and may be useful for clinicians in developing targeted treatment options.

Effects of Depressive Symptoms on Cognition, Markers of Brain Aging

Effects of Depressive Symptoms on Cognition, Markers of Brain Aging

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These findings suggest a strong association between greater depressive symptoms and markers of brain aging as well as impaired episodic memory.

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

These findings indicate that anxiety may be a risk factor for late-life dementia, excluding anxiety that is related to prodromal cognitive decline.

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

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These results suggest that antipsychotic exposure has no impact on relative mortality.

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

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Concerns over Nuplazid were initially voiced in a CNN article in early April which reported that the drug had been associated with over 700 deaths since its launch in March 2017.

Mild TBI May Increase Risk for Parkinson Disease

Mild TBI May Increase Risk for Parkinson Disease

Mild traumatic brain injury is associated with increased risk of Parkinson disease among military veterans.

Traumatic Brain Injury Associated With Increased Risk for Dementia

Traumatic Brain Injury Associated With Increased Risk for Dementia

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These data support the importance of TBI preventative measures and proper management strategies for subsequent dementia.

Isolated vomiting not linked to clinically important TBI in children

Isolated vomiting (vomiting without other predictors of traumatic brain injury [TBI] as defined by 3 high-quality clinical decision rules) was not associated with clinically important TBI or evidence of TBI on computed tomography scans among pediatric patients with head injury.

Apathy Associated With Lower Health-Related Quality of Life in Huntington Disease

Apathy Associated With Lower Health-Related Quality of Life in Huntington Disease

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These data confirm the debilitating effects of apathy on functioning in patients with Huntington disease.

Apathy: An Important Predictor of Employment in Huntington Disease

Apathy: An Important Predictor of Employment in Huntington Disease

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The authors noted that apathy is very common and progressive among Huntington disease mutation carriers, even during early stages of the disease, and has been associated with decline in general functioning.

Electrical Stimulation of Amygdala May Improve Long-term Memory

Electrical Stimulation of Amygdala May Improve Long-term Memory

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Electrical stimulation of the amygdala may boost declarative memory without influencing an emotional response.

Low Opioid Use in Veterans With Recent Traumatic Brain Injury

Low Opioid Use in Veterans With Recent Traumatic Brain Injury

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Veterans diagnosed with TBI don't use opioids very often.

Cerebrovascular Dysfunction May Affect Cognition in Primary Hyperparathyroidism

Cerebrovascular Dysfunction May Affect Cognition in Primary Hyperparathyroidism

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Primary hyperparathyroidism may be linked to lower intracerebral vasomotor reactivity, which could lead to cognitive dysfunction.

Addressing Gender Disparities in Concussion Diagnosis and Treatment

Addressing Gender Disparities in Concussion Diagnosis and Treatment

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Compared with male athletes, female athletes face a greater incidence of and longer recovery time from concussion.

Cognitive Dysfunction Evaluated by fMRI in Non-Neuropsychiatric SLE

Cognitive Dysfunction Evaluated by fMRI in Non-Neuropsychiatric SLE

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Functional MRI imaging found that in patients with non-neuropsychiatric systemic lupus erythematosus, defects in spatial working memory and cognitive dysfunction were related to damage in specific neural networks.

Neural Entrainment Through Visual, Auditory Stimulation Reduces Pain Perception

Neural Entrainment Through Visual, Auditory Stimulation Reduces Pain Perception

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Patients in the visual arm of the study wore flashing LED goggles delivering visual stimulation in the alpha-band range.

Cognitive Processes' Influence on Pain Perception

Cognitive Processes' Influence on Pain Perception

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Evidence indicates that distraction can provide pain relief, highlighting the influence cognitive processes have on pain perception.

Midlife Hypertension and Late-life Neurocognitive Status

Midlife Hypertension and Late-life Neurocognitive Status

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The American Heart Association issues a scientific statement on the possible link between chronic arterial hypertension and cognitive impairment.

Late-life Volunteering Helps Maintain Cognitive Function

Late-life Volunteering Helps Maintain Cognitive Function

Regular late-life volunteering is independently tied to decreased risk of cognitive impairment.

Is There a Link Between Midlife Hypertension and Late-life Cognitive Dysfunction

Is There a Link Between Midlife Hypertension and Late-life Cognitive Dysfunction

The American Heart Association issues a scientific statement on the possible link between chronic arterial hypertension and cognition.

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