Higher Blood Pressure at Midlife Increases Risk for Dementia

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Systolic blood pressure ≥130 mm Hg at age 50, below the conventional ≥140 mm Hg threshold used to define hypertension, is associated with increased risk of dementia.
Systolic blood pressure ≥130 mm Hg at age 50, below the conventional ≥140 mm Hg threshold used to define hypertension, is associated with increased risk of dementia.

HealthDay News — The risk for dementia is increased in 50-year-olds with blood pressure ≥130 mm Hg, which is below the current threshold for hypertension, according to a study published online June 13 in the European Heart Journal.

Jessica G. Abell, Ph.D., from University College London, and colleagues examined associations of diastolic and systolic blood pressure (SBP) at age 50, 60, and 70 years and incidence of dementia among 8,639 participants (32.5 percent women) of the Whitehall II cohort study.

The researchers found that through 2017 there were 385 incident cases of dementia. SBP ≥130 mm Hg at age 50 years, but not at age 60 or 70 years, was associated with increased risk of dementia. These results persisted when adjusting for sociodemographic factors, health behaviors, and time-varying chronic conditions (hazard ratio, 1.38; 95 percent confidence interval, 1.11 to 1.70). There was no association between diastolic BP and dementia. Patients with longer exposure to hypertension (SBP ≥130 mm Hg) between mean ages of 45 and 61 years had an increased risk of dementia versus those with no or low exposure to hypertension (hazard ratio, 1.29; 95 percent confidence interval, 1.00 to 1.66).

"Systolic blood pressure ≥130 mm Hg at age 50, below the conventional ≥140 mm Hg threshold used to define hypertension, is associated with increased risk of dementia; in these persons this excess risk is independent of cardiovascular disease," the authors write.

Abstract/Full Text

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