Generic Name and Formulations:
Nesiritide 1.5mg/vial; pwd for IV inj after reconstitution and dilution; contains mannitol.
Indications for NATRECOR:
Acutely decompensated CHF with dyspnea at rest or with minimal activity.
2mcg/kg IV bolus once, then 0.01mcg/kg per minute by continuous IV infusion; limited experience with therapy >96 hours. Doses up to 0.03mcg/kg per minute have been used; see full labeling. Reduce dose or discontinue if symptomatic hypotension occurs.
Persistent systolic BP <100mmHg. Cardiogenic shock.
Not recommended in significant valvular stenosis, restrictive or obstructive cardiomyopathy, constrictive pericarditis, pericardial tamponade, other conditions where vasodilators are inappropriate, or when cardiac output is dependent on venous return, or in patients with low cardiac filling pressures. Impaired renal function (esp if severe heart failure); monitor serum creatinine during and after therapy until stabilized. Monitor BP closely. Pregnancy (Cat.C). Nursing mothers.
Hypotension potentiated by ARBs and/or ACE inhibitors.
Vasodilator (human B-type natriuretic peptide).
Hypotension, headache, nausea, back pain, dizziness; hypersensitivity.
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Triiodothyronine in the Treatment of Bipolar Depression
- Antidepressants Increase Seizure Risk in Youth and Severely Depressed
- Intranasal Oxytocin Reduces Negative Effects, Improves Cognitive Function in Schizophrenia
- E-Cigarettes Associated With More Harms Than Benefits at Population Level
- Examining Rates of Long-Term Opioid Use in Youth With Psychiatric Disorders
- Suicide-Screening Toolkit Can Help Identify Youths at High Risk for Suicide
- Researchers Identify Novel Potential Biomarkers for Autism
- Agoraphobia: An Evolving Understanding of Definitions and Treatment
- Parental Pressure to Diet Linked With Long-term Harm in Adolescents
- Does Access to Medical Cannabis Reduce Risk for Opioid Abuse?
- Supported Employment vs Transitional Work in Veterans With PTSD
- Comparing Pharmacologic Treatments for Prevention of Rehospitalization in BP
- Preliminary Evidence Suggests Suicidal Thinking Is Self-Reinforcing
- Lower Fluoxetine Efficacy in Elderly Patients With Major Depressive Disorder
- Personal Health Information Found in Recycling