Generic Name and Formulations:
Nabumetone 500mg, 750mg; tabs.
Various generic manufacturers
Indications for Nabumetone:
Rheumatoid arthritis. Osteoarthritis.
Initially 1g once daily; max 2g/day in 1 or 2 divided doses. Renal insufficiency (CrCl 30–49mL/min): initial max 750mg once daily, may increase to 1.5g/day; (CrCl <30mL/min): initial max 500mg once daily, may increase to 1g/day.
Aspirin allergy. 3rd trimester pregnancy. Coronary artery bypass graft surgery.
Advanced renal disease: not recommended. History of upper GI disease or other ulcer risk. Cardiovascular disease. Renal or severe hepatic impairment. Fluid retention. Heart failure. Hypertension. Asthma. Monitor BP, renal and hepatic function. Discontinue if hepatic dysfunction or skin rash occurs. Monitor hemoglobin or hematocrit if signs of anemia occur. Avoid sun, UV light. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Renal toxicity potentiated with diuretics. May potentiate lithium. May antagonize ACE inhibitors. Monitor oral anticoagulants (eg, warfarin). Caution with methotrexate.
GI bleeding or upset, edema, photosensitivity, dry mouth, dizziness, headache, fatigue, sweating, insomnia, nervousness, somnolence, rash (discontinue if occurs), pruritus, tinnitus. See literature re: risk of cardiovascular events.
Formerly known under the brand name Relafen.
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Adjunctive Therapies for Bipolar Disorder Show Promise, Need More Evidence
- Predicting Treatment-Emergent Mania to Tailor Pharmacotherapy in Bipolar Disorder
- Abnormalities of Cortical Thickness in Bipolar Disorder With Auditory Hallucinations
- Prevalence of ADHD Relatively Stable Over Time Despite Increase in Diagnoses
- Genetic Variations Associated With Empathy Affect Psychiatric Conditions
- The Way to the Head May Be Through the Gut: Probiotics for Depression
- Suicide-Screening Toolkit Can Help Identify Youths at High Risk for Suicide
- Agoraphobia: An Evolving Understanding of Definitions and Treatment
- Parental Pressure to Diet Linked With Long-term Harm in Adolescents
- Does Access to Medical Cannabis Reduce Risk for Opioid Abuse?
- Examining Rates of Long-term Opioid Use in Youth With Psychiatric Disorders
- Mortality Rates for Substance Use Disorders, Intentional Injuries Vary Widely By Country
- Facial Emotion Recognition Differentiates Behavioral Variant Frontotemporal Dementia From MDD
- The Challenge of Helping Uninsured Patients While Protecting Practice Finances
- Antidepressants Increase Seizure Risk in Youth and Severely Depressed