Generic Name and Formulations:
Primidone 50mg, 250mg; scored tabs.
Valeant Pharmaceuticals, Inc
Indications for MYSOLINE:
Tonic-clonic, focal and psychomotor seizures.
Initially: 100–125mg at bedtime. Increase every 3 days if needed by 100–125mg daily to 3 times daily on day 7. On day 10, increase to 250mg 3 times daily; max 2g daily in divided doses.
<8yrs: initially 50mg at bedtime. On day 4, increase if needed to 50mg twice daily. On day 7, to 100mg twice daily. On day 10, to 125–250mg 3 times daily. Usual maintenance: 100–250mg 3 times daily or 10–25mg/kg/day in divided doses. ≥8yrs: as adult.
Porphyria. Barbiturate hypersensitivity.
Impaired liver function. Change dose gradually. Monitor blood counts, electrolytes. Pregnancy. Nursing mothers.
Potentiated with alcohol and other CNS depressants. Antagonizes oral anticoagulants and contraceptives, steroids, Vit. K and D, griseofulvin, doxycycline. Variable effects with phenytoin, valproic acid, divalproex. Potentiated by MAOIs. Antagonizes tricyclic antidepressants.
Drowsiness, ataxia, dizziness, nystagmus, neonatal hemorrhage and withdrawal, nausea, vomiting, rash, megaloblastic anemia sensitive to folic acid, emotional disorders, impotence.
Tabs 50mg—100, 500; 250mg—100, 1000
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Rapid Cycling in Bipolar Disorder: Overview and Expert Perspectives
- First-Episode Drug-Naive Patients With Schizophrenia More Likely to Attempt Suicide
- Posttraumatic Stress Disorder Associated With Reduced Brain Volume
- Early Childhood Out-of-Home Placement Associated With Adverse Outcomes in Adulthood
- ADHD Medications Compared for Efficacy, Tolerability in Children and Adults
- The Psychology of Hoarding Disorder: Approaches for Treatment
- Mind-Body Therapy and Psychiatry: Ancient Tools for Modern Practice
- Smartphone Applications for Depression and Anxiety: Are They Ready for Widespread Use?
- The Many Misconceptions of Catatonia: Treatment Is Often Successful With the Right Knowledge
- Marijuana Use Associated With Poorer Depression Outcomes, Increased Suicidal Ideation
- Symptoms of Anxiety, Depression Differ Depending on Gender, Race, Ethnicity
- Examining Whether Adjunctive Glutamatergic Medication Further Eases OCD Symptoms
- FDA Permits Marketing of Brain Stimulation Device for OCD
- Antipsychotics Adversely Affect Adiposity and Insulin Sensitivity in Youths
- Know Before You Go: Practicing Medicine Abroad