A team of scientists claims to have finally started to understand what goes wrong in schizophrenia, following the discovery that disease-linked mutations disrupt genes responsible maintaining a chemical balance in the brain crucial for healthy brain development and function.

The mutations disrupt genes that regulate excitatory and inhibitory neurotransmission, which needs to be delicately balanced to ensure the brain functions properly.

The healthy functioning of a brain is dependent on the balance between chemical signals that regulate the activity of nerve cells. In the past, psychiatric disorder experts have suggested that disruption of this balance could contribute to the development of schizophrenia.

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