Genetic Variant May Explain What Causes Schizophrenia

Depression, bipolar disorder, and schizophrenia have more in common than previously thought.
Depression, bipolar disorder, and schizophrenia have more in common than previously thought.
Symptoms of schizophrenia, including agitation and memory problems, linked to a single genetic variant known as Arp2/3.

Schizophrenia is one of psychiatry’s most puzzling afflictions, with a complex of symptoms that goes far beyond its hallmark hallucinations and delusional thinking.

But new research has found connections among several of schizophrenia’s peculiar collection of symptoms — including agitation and memory problems — and linked them to a single genetic variant among the hundreds thought to heighten risk of the disorder.

The findings offer new insights into the molecular basis for schizophrenia and could lead to treatments for the disease that are more targeted and more comprehensive.

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