Smoking increases the metabolism of clonidine through the CYP1A2, which may require the dose to be doubled to have the same plasma concentration as a non-smoker.
In a study, perceptual updating was assessed via a random dot motion perception task. Midway through the test, the motion direction changed. Study participants were then asked to report the direction.
The approval was based on data from an ongoing phase 3 trial evaluating the safety and tolerability of brexpiprazole as maintenance treatment of 194 patients aged 13 to 17 years with schizophrenia.
Researchers are exploring affective lability as a therapeutic target for bipolar disorder, but limited evidence exists on its prevalence and impact among people with schizophrenia and other psychosis spectrum disorders.
Researchers examined nationwide data from the Welsh Demographic Service Dataset to determine if absence and exclusion from school were associated with a record of neurodevelopmental disorder, mental disorder, and self-harm.
