Smoking increases the metabolism of clonidine through the CYP1A2, which may require the dose to be doubled to have the same plasma concentration as a non-smoker.
A comparative list of psychotropic medications with their mood disorder indications (bipolar disorder, major depressive disorder, treatment resistant depression, premenstrual dysphoric disorder, and others).
The study authors evaluated whether psychosis transition can be predicted in patients with clinical high-risk or recent-onset depression using multimodal machine learning that integrates clinical and neurocognitive data, structural magnetic resonance imaging, and polygenic risk scores for schizophrenia.
In this study participants used a multi-modal smartphone data collection system to report on their AVH experiences and co-occurring psychological states multiple times daily, over 30 days. At the same time, smartphone sensors recorded their physical activity, geolocation, and calling and texting behavior.
