Elevated risk for schizophrenia was linked to a 10 ug/m3 increase in daily childhood NO2 exposure (adjusted hazard ratio, 1.27) and a 1-SD increase in polygenic risk score (adjusted hazard ratio, 1.29).
During the mean follow-up (3.57±1.62 years), severe hepatic outcomes occurred in 22 patients (5.47%), and of these, 2 people (1.49%) were receiving paliperidone.
The study examined 3 psychotic phenotypes: psychosis wide, psychosis narrow, and delusions narrow.
Originally conceptualized by medical anthropologist Merrill Singer, a syndemic can be defined as “an aggregation of two or more diseases or other health conditions in a population…that exacerbates the negative health effects of…the diseases.”
The relationship between internalizing symptoms and psychotic-like experiences was similar for probable depression (OR, 1.08; 95% CI, 1.03-1.14; P =.003) and anxiety disorder (OR, 1.11; 95% CI, 1.05-1.17; P <.001).
According to the researchers, other published data suggest that visual deprivation causes increases in NMDAR-dependent cortical excitability.
Greater severity of depressive symptoms was significantly associated with increased severity of positive (P =.002) and negative (P =.003) schizophrenia symptoms.
A tenfold increase in the prevalence of schizophrenia in patients with HS underscores the importance of screening for severe mental illness, as comorbid psychiatric disorders may affect treatment outcomes.
A Finnish study published in BMJ found key differences in the conceptions of psychiatric diseases among the general public, physicians, nurses, and legislators.
Although prior research suggests that heritability accounts for 66% to 85% of schizophrenia risk, additional risk factors include stress and the “nature of caregiving,” or the home environment and caregiver conduct.