Schizophrenia, Bipolar Disorder, and the Psychosis Continuum
Awareness of differences between psychosis in schizophrenia and bipolar disorder and varying presentations in patients can assist providers with diagnosis and treatment.
Schizophrenia and Psychoses
SCHIZOPHRENIA AND PSYCHOSES
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Nitrogen Dioxide May Raise Schizophrenia Risk, Even When Accounting for Polygenic Factors
Elevated risk for schizophrenia was linked to a 10 ug/m3 increase in daily childhood NO2 exposure (adjusted hazard ratio, 1.27) and a 1-SD increase in polygenic risk score (adjusted hazard ratio, 1.29).
Paliperidone May Reduce Risk for Severe Hepatic Outcomes in Patients With Schizophrenia and Hepatitis
During the mean follow-up (3.57±1.62 years), severe hepatic outcomes occurred in 22 patients (5.47%), and of these, 2 people (1.49%) were receiving paliperidone.
Shared Genetic Liability Observed for Schizophrenia, Psychosis in Alzheimer Disease
The study examined 3 psychotic phenotypes: psychosis wide, psychosis narrow, and delusions narrow.
Syndemic Effects May Explain Ethnic Disparities in Psychotic Experiences
Originally conceptualized by medical anthropologist Merrill Singer, a syndemic can be defined as “an aggregation of two or more diseases or other health conditions in a population…that exacerbates the negative health effects of…the diseases.”
In Adolescents, Psychotic-Like Experiences Predict Future Psychiatric Illness
The relationship between internalizing symptoms and psychotic-like experiences was similar for probable depression (OR, 1.08; 95% CI, 1.03-1.14; P =.003) and anxiety disorder (OR, 1.11; 95% CI, 1.05-1.17; P <.001).
How Does a Visual Construction of the World Influence Psychosis?
According to the researchers, other published data suggest that visual deprivation causes increases in NMDAR-dependent cortical excitability.
Depression Highly Prevalent in First-Episode Schizophrenia
Greater severity of depressive symptoms was significantly associated with increased severity of positive (P =.002) and negative (P =.003) schizophrenia symptoms.
Higher Risk for Schizophrenia in Those With Hidradenitis Suppurativa
A tenfold increase in the prevalence of schizophrenia in patients with HS underscores the importance of screening for severe mental illness, as comorbid psychiatric disorders may affect treatment outcomes.
Divergence of Lay and Professional Conceptions of Psychiatric Disease
A Finnish study published in BMJ found key differences in the conceptions of psychiatric diseases among the general public, physicians, nurses, and legislators.
Lower Parental Income in Childhood Associated With Schizophrenia Risk
Although prior research suggests that heritability accounts for 66% to 85% of schizophrenia risk, additional risk factors include stress and the “nature of caregiving,” or the home environment and caregiver conduct.
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