Smoking increases the metabolism of clonidine through the CYP1A2, which may require the dose to be doubled to have the same plasma concentration as a non-smoker.
The researchers sought to estimate the age-specific incidence and prevalence of dementia diagnoses among older adults with schizophrenia in the United States compared to those without serious mental illness.
While cross-sectional studies have reported elevated concentrations of inflammatory markers in psychosis and depression, there are questions regarding temporality and specificity of association, crucial for understanding the potential role of inflammation.
The goal for this phase 2 trial was to assess the efficacy and safety of the combination oral agent xanomeline-trospium in patients with acute exacerbations of schizophrenia.
The study authors investigated expressed genes and gene transcripts in the postmortem subgenual anterior cingulate cortex, a key component of limbic circuits linked to mental illness, in order to determine how gene expression in the brain is different across psychiatric illnesses.
The study authors explored the odds of significant COVID-19 morbidity and mortality among schizophrenia patients while controlling for potential sociodemographic and medical confounders.
This study compared the baseline clinical characteristics and therapeutic outcomes of outpatients with multimodal or unimodal (auditory) hallucinations.
Delivery of antipsychotic drugs via the nasal cavity circumvents multiple barriers for reaching the brain but requires a vehicle with specific properties to be effective.
