Parkinson’s Disease

Latest News

Air Pollution Tied to Neurological Disorders in Seniors

Exposure to air pollution is associated with an increased risk for neurological disorders in older adults.

Pimavanserin Associated with Significant Improvement in Anxious Depression

By

Heather R. Johnson

In this post hoc analysis, the effect of pimavanserin on anxious depression was determined from CLARITY, a randomized, double-blind, placebo-controlled study in patients with major depression and an inadequate response to previous therapy.

Skin α-Synuclein Aggregation Seeding Activity: A Possible Biomarker for Parkinson Disease

By

Jessica Nye, PhD

This retrospective and prospective diagnostic study evaluated autopsy and biopsy skin samples from neuropathologically and clinically diagnosed patients with Parkinson Disease and controls without PD.

Caffeine Metabolism May Be Marker of Risk for Parkinson Disease in Those With LRRK2 Gene Mutation

By

Emily Pond

To identify markers of resistance to developing Parkinson disease among LRRK2 mutation carriers, metabolomic profiling in individuals with Parkinson disease and unaffected controls, were carried out with and without the LRRK2 mutation.

Stem Cell-Derived Neurons Provide Clues Into Parkinson Disease

By

Heather R. Johnson

After transplanting hESC-derived midbrain dopamine (mDA) into the striatum of a PD model mouse, researchers found extensive graft integration with host circuitry.

Comparing the Quality of Life in Parkinson Disease Patients With Subthreshold Depression vs Patients With No Depressive Disorder

By

Heather R. Johnson

Subthreshold depression was found to be a problem with Parkinson Disease patients. Quality of life is worse and non-motor symptoms burden is greater.

Pimavanserin Effective for Depression in Parkinson Disease, Major Depressive Disorder

By

Jessica Nye, PhD

Researchers conducted an 8-week, open-label, single-arm study and a subsequent 2-stage, sequential, parallel comparison study to assess the use of pimavanserin among patients with Parkinson disease and major depressive disorder.

Reduced Circadian Rhythmicity Tied to Increase in Parkinson Disease

Reduced circadian rhythmicity is associated with an increased risk for incident Parkinson disease.

Imaging May Predict Parkinson Disease Progression in Older Adults

By

Madeline Morr

Researchers sought to determine the relationship between neuroimaging markers and other clinical characteristics with mild parkinsonian signs in older adults.

The Role of Precision Medicine in Parkinson Disease

By

Amit Akirov, MD

Precision medicine offers a promising therapeutic strategy for patients with Parkinson disease, allowing for tailored treatments which reflect the unique pathophysiology in each patient.