Genetic Variant Accelerates Cognitive Decline in Parkinson’s

Cognitive impairment is a common and disabling problem in Parkinson’s disease (PD) that is not well understood and is difficult to treat. Identification of genetic variants that influence the rate of cognitive decline or pattern of early cognitive deficits in PD might provide a clearer understanding of the etiopathogenesis of this important nonmotor feature.

The objective of the study is to determine whether common variation in the APOE, MAPT, and SNCA genes is associated with cognitive performance in patients with PD.

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