Cognitive Decline in Parkinson Disease Linked With Alzheimer Genetic Variants

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Multiple genetic risk loci for Alzheimer disease predict longitudinal cognitive decline in patients with Parkinson disease without dementia.

The following article is part of conference coverage from the 2019 American Academy of Neurology Annual Meeting (AAN 2019) in Philadelphia, PA. Neurology Advisor’s staff will be reporting breaking news associated with research conducted by leading experts in neurology. Check back for the latest news from AAN 2019.

PHILADELPHIA — Variant genotypes associated with Alzheimer disease also predict decline of cognitive performance in patients with Parkinson disease, according to research presented at the 2019 American Academy of Neurology Annual Meeting, held May 4-10, 2019, in Philadelphia, Pennsylvania.

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The investigators of this study sought to evaluate the role of common genetic variants, or susceptibility loci, for Alzheimer disease in the development of cognitive decline and dementia in Parkinson disease. A total of 151 patients with Parkinson disease without baseline dementia were followed for a mean 2.9 years. A linear mixed effects model was applied to test associations between cognitive performance and single nucleotide polymorphisms in previously identified loci related to Alzheimer risk.

The investigators found that the presence of single nucleotide polymorphisms at susceptibility loci CR1, BIN1, CLU, and PICALM, which were previously associated with risk of developing Alzheimer disease, were also predictive of longitudinal cognitive decline in patients with Parkinson disease.

The investigators suggest that further long-term studies are needed to replicate these findings.

Disclosure: Multiple authors disclosed affiliations with pharmaceutical companies. See the reference for complete disclosure information.

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Baratta L, Tropea T, Maddy K, et al. Alzheimer’s disease genetic risk variants predict cognitive decline in Parkinson’s disease. Presented at: 2019 American Academy of Neurology Annual Meeting; May 4-10, 2019; Philadelphia, PA. Abstract P2.8-026.

This article originally appeared on Neurology Advisor