Neuropsychiatric symptoms in the presence of mild cognitive impairment (MCI), including depression, appear to significantly increase the risk of conversion to dementia —either amnestic or Alzheimer’s type-dementia — according to a study released today by AJP in Advance.

Diabetes and prediabetes increased risk of conversion from amnestic MCI to Alzheimer’s dementia and from any-type or nonamnestic MCI to all-cause dementia. But the researchers also found that the presence of neuropsychiatric symptoms predicted conversion to all-cause dementia, and depressive symptoms predicted conversion from any-type MCI to all-cause dementia in epidemiological but not clinical studies.

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