Impaired Brain Signaling Pathway May Cause Alzheimer’s

Exactly what causes Alzheimer’s is unclear, which is primarily why scientists have yet to find a cure for the disease. But could this soon change? Researchers from the Mayo Clinic in Jacksonville, Florida, have identified a defect in a brain signaling pathway that they believe contributes to the development of Alzheimer’s, which could lead to disease prevention strategies or treatments for its early stages.

The Mayo Clinic team found that low levels of a protein that regulates beta-amyloid production and nerve cell communication interferes with signaling in the Wnt pathway — known to be important for embryonic development, cell survival and synaptic activity crucial for memory and learning. 

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