Changes in Certain Biomarkers Midlife May Predict Dementia

Biomarkers For Early Alzheimer's Disease Detection
Biomarkers For Early Alzheimer’s Disease Detection
Changes in biomarkers found in cerebrospinal fluid and brain scans, such as amyloid and tau protein, at middle age may predict who will develop dementia.

Studying brain scans and cerebrospinal fluid of healthy adults, scientists have shown that changes in key biomarkers of Alzheimer’s disease during midlife may help identify those who will develop dementia years later, according to new research.

The study, at Washington University School of Medicine in St. Louis, is published in JAMA Neurology.

The study focused on data gathered over 10 years and involved 169 cognitively normal research participants ages 45 to 75 when they entered the study. Each participant received a complete clinical, cognitive imaging and cerebrospinal fluid biomarker analysis every three years, with a minimum of two evaluations.

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