Blood Biomarker Could Predict Alzheimer’s Decade Before Symptoms

Blood Tests May Help Predict ALS Survival
Blood Tests May Help Predict ALS Survival
Identical twins that had lower levels of the protein MAPKAPK5 tended to have a decline in cognitive abilities over a 10-year period.

Scientists at King’s College London have identified a single blood protein that may indicate the development of Mild Cognitive Impairment (MCI) years before symptoms appear, a disorder that has been associated with an increased risk of Alzheimer’s disease or other dementias.

The new research, published today in Translational Psychiatry, used data from over 100 sets of identical twins from TwinsUK, the biggest adult twin cohort in the UK. The use of twins in the study indicated that the association between the blood protein and a ten year decline in cognitive ability was independent of age and genetics, both of which are already known to affect the risk of developing Alzheimer’s disease, the most common form of dementia.

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