Alzheimer’s Disease May Have Roots in Vascular System

Alzheimer's Disease May Have Roots in Vascular System
Alzheimer’s Disease May Have Roots in Vascular System
Theory holds that Alzheimer's disease is caused by bleeding in the brain, the result of high blood pressure and hardening of the aorta.

The prevailing medical wisdom that Alzheimer’s disease has its origins in the brain has a radical and disputed rival with shocking implications for medicine’s relentless efforts to forestall disease, aging and death, according to a new review of the evidence.

The established medical view is that Alzheimer’s is primarily a degenerative disease of the brain caused by the effects of accumulating protein deposits — known as “beta-amyloid” senile plaques and “neurofibrillary tangles” — that interfere with neural pathways and signaling.

But the alternative explanation argues that aged-related dementia has an earlier origin in the heart and vascular system, not the brain. 

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