HealthDay News — The association between obesity and subsequent dementia varies with the age at which obesity is first recorded, according to a study published online in the Postgraduate Medical Journal.

Clare J. Wotton and Michael J. Goldacre, BM, BCh, from the University of Oxford in the United Kingdom, and colleagues utilized national administrative statistical data on hospital care and mortality in England (1999 to 2011) to identify 451,232 people with obesity and a cohort of controls.

The researchers found that the risk for dementia in people admitted to the hospital with obesity at 30 to 39 years of age was significantly increased (risk ratio [RR], 3.5). Increasing age at obesity gradually reduced the risk for dementia, from 1.7 in people aged 40 to 49 years when obesity was first recorded to 1.4 in those whose obesity was first recorded at 60 to 69 years. There was neither an increased nor a reduced risk of subsequent dementia for people whose obesity was first recorded in their 70s (RR, 0.97; 95% confidence interval, 0.93 to 1.01), while those aged ≥80 years had a reduced risk of subsequent dementia (RR, 0.78; 95% confidence interval, 0.74 to 0.82).

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“While obesity at a younger age is associated with an increased risk of future dementia, obesity in people who have lived to about 60 to 80 years of age seems to be associated with a reduced risk,” the authors write.


  1. Wotton CJ, et al. Postgrad Med J. doi:10.1136/postgradmedj-2014-132571