Alzheimer Disease and Dementia

Latest News

Lower Kidney Function May Up Dementia Risk in Older Adults

In addition, steeper decline in eGFR within one year associated with higher dementia risk

Novel, Rare Variants Associated With Alzheimer Disease and Replicated in an Independent Cohort

By

Jessica Nye, PhD

The study researchers used deep whole-genome sequencing (WGS) to search for novel AD variants in 2247 individuals from 605 multiplex AD families from the National Institute on Mental Health and the National Institute on Aging (NIA) Alzheimer’s Disease Sequencing Project `data sets.

Younger Age at T2D Onset Linked to Subsequent Dementia Risk

Younger age at onset of type 2 diabetes is associated with an increased risk for subsequent dementia.

Case Study: Amyloid-PET Positive Patient With Frontotemporal Behavioral Dementia

By

Mary Stroka

Researchers evaluated a case study of a patient who was diagnosed with frontotemporal behavioral dementia whose autopsy showed coexistent TDP-43 type A and Alzheimer disease pathologies and cerebrovascular disease.

History of Depression, Anxiety Inversely Correlates With Age of Onset in Alzheimer Disease

By

Mary Stroka

There may be an association between a history of psychiatric disorders in patients and age of onset of Alzheimer disease.

Progression of β-Amyloid Deposition and Consequences on Cognitive Impairment

By

Jessica Nye, PhD

Evidence suggests the importance of decreasing -amyloid deposition in brains of patients with Alzheimer disease early in care.

Lewy Body Dementia With AD Copathology Linked to Impaired Language Performance

By

Mary Stroka

Patients with Lewy body dementia with likely AD-type copathology may have impaired language compared to those without such copathology.

Study Shows Ongoing Loneliness Increases Dementia Risk

By

Heather R. Johnson

Persistent loneliness in midlife is associated with a higher risk of Alzheimer disease (AD) and other dementias. The good news is that people who bounce back from loneliness build resilience to dementia and AD.

African Americans More Likely to Carry Genetic Variants Associated With Dementia

By

Brandon May

Study researchers sought to assess the racial differences in triggering receptor expressed on myeloid cells 2 in patients with Alzheimer disease.

FDA Rejects Pimavanserin sNDA for Dementia-Related Psychosis

By

Brian Park, PharmD

The sNDA submission was supported by data from the pivotal phase 3 HARMONY study.