Alzheimer Disease and Dementia

Latest News

P-tau217 Shows Promise as Biomarker for Alzheimer Disease

Plasma tau phosphorylated at threonine 217 (P-tau217) shows promise as a biomarker for Alzheimer disease.

Dual Sensory Impairment Ups Dementia Risk

Older adults with both hearing and visual impairments — dual sensory impairment — are at a significantly increased risk for dementia.

Vaccination Linked to Reduced Alzheimer Disease Risk

By

Cassandra Pardini, PharmD

At AAIC 2020, 2 presentations separately discussed observing a reduced risk of AD in patients who received the influenza and pneumonia vaccines.

Frontal Lobe Cognitive Dysfunction Symptom Reduction Associated With Rotigotine Therapy

By

Madeline Morr

Researchers conducted a randomized clinical trial to assess whether 24 weeks of treatment with rotigotine can modify cognitive functions in patients with mild to moderate Alzheimer disease.

Surgery in Older Adults Does Not Increase Risk for Alzheimer Disease

Older adults who have surgery with general anesthesia may experience a modest cortical thinning in the brain, but it does not appear to be tied to Alzheimer disease.

Aducanumab BLA for Alzheimer Disease Submitted for FDA Review

By

Brian Park, PharmD

Biogen has submitted its Biologics License Application (BLA) to the Food and Drug Administration (FDA) for aducanumab as a treatment of Alzheimer disease (AD).

Brain Iron Concentrations Increased in Alzheimer Disease

Patients with Alzheimer disease have increased iron concentration in the deep gray matter and neocortical regions compared with healthy controls.

Increased Body Weight, Obesity Linked to Dementia Incidence

Having increased body weight or abdominal obesity is associated with increased incidence of dementia.

Novel Therapy for Alzheimer Disease Agitation Gets Breakthrough Designation

By

Brian Park, PharmD

The FDA has granted Breakthrough Therapy designation to AXS-05 (Axsome Therapeutics) for the treatment of Alzheimer disease (AD) agitation.

Women Have More Brain Changes Related to Alzheimer Disease

Cognitively normal women have increased Alzheimer disease endophenotype, with higher β-amyloid deposition, lower glucose metabolism, and lower gray and white matter volumes.