Persistent loneliness in midlife is associated with a higher risk of Alzheimer disease (AD) and other dementias. The good news is that people who bounce back from loneliness build resilience to dementia and AD.
Study researchers sought to assess the racial differences in triggering receptor expressed on myeloid cells 2 in patients with Alzheimer disease.
The sNDA submission was supported by data from the pivotal phase 3 HARMONY study.
The researchers sought to estimate the age-specific incidence and prevalence of dementia diagnoses among older adults with schizophrenia in the United States compared to those without serious mental illness.
Investigators assessed white matter hypeintensity burden in patients with Alzheimer disease and behavioral-variant frontotemporal dementia.
Head injury is associated with dementia over a median 25 years of follow-up.
For patients with early symptomatic Alzheimer disease, donanemab, which targets a modified form of deposited amyloid-ß, results in slightly less cognitive and functional decline than placebo.
Older women may have greater cognitive reserve but faster cognitive decline than men.
Higher plant protein intake and substitution of animal protein with plant protein are associated with a lower risk for all-cause, cardiovascular disease, and dementia mortality in women.
Treatment with atabecestat may be associated with dose-related cognitive worsening in patients with preclinical Alzheimer disease.