Alzheimer Disease and Dementia

Latest News

Suvorexant Evaluated for Insomnia in Patients With Alzheimer Disease Dementia

By

Diana Ernst, RPh

Results from a study evaluating the safety and efficacy of suvorexant (Merck) for the treatment of insomnia in patients with mild to moderate Alzheimer disease dementia were presented at the AAN meeting.

Treatment Shows Promise for Agitation in Alzheimer Dementia Patients

By

Da Hee Han, PharmD

Avanir announced data from the phase 3 clinical program that evaluated AVP-786 (deudextromethorphan hydrobromide/quinidine sulfate) for the treatment of moderate-to-severe agitation in patients with Alzheimer dementia.

Alzheimer Disease Trials Discontinued Following Disappointing Results With Aducanumab

By

Diana Ernst, RPh

Biogen and Eisai have made the decision to discontinue two phase 3 trials evaluating aducanumab for the treatment of mild cognitive impairment due to Alzheimer disease (AD) and mild AD dementia.

Having Affected Relatives Linked to Increased Alzheimer Risk

Having affected first-degree, second-degree, or third-degree relatives is associated with an increased risk for Alzheimer disease.

Tau PET May Be Best to Detect Early Cognitive Changes in Alzheimer Disease

By

Brandon May

Researchers analyzed the cross-sectional relationships among regional tau, β-amyloid, and cortical thickness and neuropsychological function in Alzheimer disease.

Racial Differences Identified in Some Biomarkers of Alzheimer Disease

Differences in Alzheimer biomarkers suggest possible race-dependent biological mechanisms that contribute to expression of disease.

Physical Frailty Associated With Symptoms of Dementia, Caregiver Burden in Alzheimer Disease

By

Emily Pond

Per study data published in the Journal of Clinical Psychiatry, investigators hypothesized that the correlation between higher Frailty Index scores and increased caregiver burden was partially mediated by increased behavioral and psychological symptoms of dementia.

Trazodone: Not Safer Than Atypical Antipsychotics in Patients With Dementia

By

Laurel Ranger

The use of trazodone in older patients with dementia was associated with similar levels of risk for falls and fractures as atypical antipsychotics.

Prevalence of Alzheimer Disease, Related Dementia Set to Double

The burden of Alzheimer disease and related dementias (ADRD) is expected to increase to 3.3% in the United States by 2060.

Apathy Associated With Increased Risk for Dementia

By

Abigail Nover

These findings have high clinical relevance because patients with apathy are likely to withdraw from care.