Alzheimer Disease and Dementia

Latest News

Variants of Apolipoprotein E May Be Novel Biomarkers for Late-Onset Alzheimer Disease

By

Jessica Nye, PhD

Despite the many loci associated with late-onset Alzheimer disease, researchers are still short of a robust, unified method of risk stratification based on genome variations due to the clinical heterogeneity and polygenic nature of the disease.

Anosognosia May Serve as an Early Indicator of Alzheimer Disease

By

Heather R. Johnson

This study looks at how the lack of awareness (anosognosia) of memory impairment evolves in the trajectory of Alzheimer disease.

In Older Adults with Cognitive Impairment, Amyloid-β (Aβ) Deposition May Be Linked to Air Pollution

By

Emily Pond

Amyloid-β (Aβ) deposition, a feature of Alzheimer disease, may be promoted by external factors. The researchers of this study examined the association between the likelihood of amyloid positron emission tomography (PET) scan positivity and ambient air quality in individuals with cognitive impairment.

Disparities Persist in Dementia Risk of Black and White Adults

By

Mary Stroka

Researchers analyzed data from a nationally representative study of older non-Hispanic Black and White adults to evaluate progress toward reducing racial disparities regarding dementia.

Air Pollution May Up Alzheimer Disease Risk in Elderly

Late-life exposure to particulate matter with aerodynamic diameter <2.5 µm is associated with Alzheimer disease (AD) pattern similarity scores among women, corresponding to an increase in AD risk.

First Blood Test for Alzheimer Disease Available in the United States

Test from C2N Diagnostics is meant for people 60 years and older who have cognitive issues and are being assessed for Alzheimer disease

Anxiety May Hasten Progression to Alzheimer Disease

ApoE4 genotype, anxiety, and lower hippocampal and entorhinal cortex volumes are associated with an elevated progression rate from mild cognitive impairment to Alzheimer disease.

Inefficient Sleep May Forecast Risk of Alzheimer Disease

By

Mary Stroka

Reduced slow-wave activity during non-rapid eye movement sleep and low sleep efficiency, both of which sleep assessments can measure, may be part of biomarkers that forecast the rate of cortical β-amyloid deposition in the brain.

Additional Alleles in the Apolipoprotein E Region May Increase Risk for Alzheimer Disease

By

Jessica Nye, PhD

This study examines whether the genetic variation near the apolipoprotein E gene (APOE) is associated with risk of Alzheimer disease independently of the ε2/ε3/ε4 genotype.

Pre-Existing Alzheimers And Dementia Associated With Risk of Hospitalization Of COVID-19

By

Mary Stroka

Researchers found in an observational cohort study that pre-existing Alzheimer disease and dementia are top risk factors for severe COVID-19 based on their association with positive tests for the coronavirus in England’s hospitals in spring 2020.