The comorbidity of depressive disorders and late-life neurodegenerative diseases including Alzheimer disease has been widely reported. This study looks into whether there is a causal relationship existing between both or, if their co-occurrence is due to confounding or common risk factors, such as aging.
Apathy is associated with an increased risk for developing probable dementia for community-dwelling older adults.
Study findings suggest that the brain age index may be an effective biomarker associated with dementia. It could also be used as a screening tool for the presence of underlying neurodegenerative disease and for the monitoring of disease progression.
Examining the risk of future dementia associated with overall alcohol consumption andalcohol-induced loss of consciousness amongst current drinkers.
The eligibility criteria of the studies include: a maximum of 10 years having passed from the study publication, geographical diversity of the studies performed, and results pertaining both to animal models of AD, and to humans.
Is there a causal relationship between depressive disorders and late-life neurodegenerative diseases? Or, is their co-occurrence due to confounding or common risk factors, such as aging?
Systolic orthostatic hypotension and variability in visit-to-visit seated systolic blood pressure postural change are associated with greater dementia risk.
MRI-based cerebrovascular reactivity is associated with cognitive function independent of Alzheimer disease pathology.
The FDA has accepted for Priority Review the Biologics License Application for aducanumab (Biogen) for the treatment of Alzheimer disease.
Years of education and the ε4 risk allele at APOE influence β-amyloid pathology in asymptomatic individuals with a parental history of sporadic Alzheimer disease, while only years of education influence β-amyloid pathology in presymptomatic autosomal dominant AD mutation carriers.