An extensive new review spotlights the struggles and societal burden associated with depression, especially when it is resistant to treatment.

Two-hundred billion dollars each year. That astounding figure might represent the annual cost of depression in the United States, according to a new systematic review encompassing more than 60 clinical studies and nearly 60,000 adult patients. At this price point, depression is more costly than cancer and diabetes, yet research on this disorder receives far less funding from the National Institutes of Health (NIH) than these other two diseases.

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