Hormonal treatments given as part of the sex reassignment process alters an individual’s brain chemistry, increasing the risk of depression in male-to-female transsexuals and lowering the risk in female-to-males, according to a new study published in the journal Biological Psychiatry. The process aligns the transsexual’s risk of depression with the established risk of their desired gender.

Researchers and doctors have long known and documented the bodily effects of gender reassignment hormonal treatments. These hormones greatly alter the secondary sexual characteristics of the adult body, shifting a recipient’s physical appearance to that of the opposite sex. Changes occur involving hair growth and texture, voice, muscle tone, complexion, and overall body shape.

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