Saffron, a spice derived from the flower of Crocus sativus, has now undergone several trials examining its antidepressant effects and, in a recent meta-analysis, was confirmed to be effective for the treatment of major depression.

The objective of the study is provide an expanded systematic analysis of the completed clinical studies on saffron and depression, detailing dosages, extract sources, standardizations, safety profile and treatment duration; and, through a narrative review, to examine its potential antidepressant mechanisms of action. 

This article originally appeared on MPR