Depressive Disorders

Researchers Question Science Behind Antidepressants

Serotonin map of brain could lead to better targeted antidepressants
Serotonin map of brain could lead to better targeted antidepressants
Several researchers say that low serotonin levels are not behind depression, and giving antidepressants to boost serotonin does more harm than good.

The science behind many antidepressant medications appears to be backwards, say the authors of a paper that challenges the prevailing ideas about the nature of depression and some of the world’s most commonly prescribed medications.

The authors of the paper, posted by the journal Neuroscience & Biobehavioral Reviews, combed existing research for evidence to support the theory that has dominated nearly 50 years of depression research: that depression is related to low levels of serotonin in the gaps between cells in the brain.

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