Depressive, anxiety and behavioral disorders may be important preceding clinical features in the onset of bipolar disorder, with the potential for targeted preventive care of at-risk individuals, study findings suggest.

Analysis of semistructured interviews with participants aged 12 to 30 years showed that these disorders were more common among 118 individuals at high genetic risk for developing bipolar disorder than 110 individuals with no family risk.

The risk was increased a significant 2.6-fold for lifetime depressive disorders, a significant 2.7-fold for anxiety disorders and a nonsignificant 3.9-fold for behavioural disorders, after considering age, gender, ethnicity and home environment.

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