In a study published in the journal Molecular Psychiatry, researchers found that the omega-3 fatty acid EPA (eicosapentataenoic acid) appears to boost mood in a subgroup of patients with major depressive disorder who have high inflammation levels.

In a randomized trial, 155 participants were given either two capsules containing EPA-enriched mix or a placebo, or four capsules of a DHA (docosahexaenoic acid)-enriched mix or four placebo capsules for eight weeks. All participants were previously diagnosed with major depressive disorder.

EPA was found to be effective for a group of patients who had high levels of at least one of four markers of inflammation in their blood. DHA was not effective for this group of patients.

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