Scientists at the University of Bath have identified that a combination of two existing licensed drugs could be used as a potential new treatment for depression.
Current antidepressants, called SSRIs, increase the amount of serotonin in the brain although the exact mechanism by which they work is still unclear. However around 30-50% of these patients do not respond to treatment, it can take several weeks before the drugs take effect, and many patients suffer significant side effects.
The team at Bath found that using a combination of buprenorphine (a painkiller used post-surgery) and naltrexone (a drug used for treating addiction) produced antidepressant-like responses in mice.
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