Many have recently questioned the efficacy of the most common antidepressant medications, the selective serotonin reuptake inhibitors (SSRIs). The conclusion that these drugs are ineffective is however partly based on a misinterpretation of the outcome of the clinical trials once conducted to demonstrate their efficacy. This was the finding of a study conducted by researchers at the Sahlgrenska Academy.

One reason for the questioning of the SSRIs has been that many of the clinical trials conducted by the pharmaceutical companies years ago to prove their efficacy failed: critics have thus pointed out that less than half of the studies demonstrated a statistically significant difference between the tested SSRI and placebo.

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