When it comes to your health, mind over matter may not be so much of a thing as mind and then matter.

In the January 2015 edition of Psychotherapy and Psychsomatics, a group of Italian researchers explored whether depression, anxiety, and other psychiatric mood disorders might be early symptoms of medical disorders, as opposed to being “just” psychological symptoms.

Their research showed that depression in particular can be a strong indicator of other forms of illness, finding it “to be the most common affective prodrome [early symptom] of medical disorders and was consistently reported in Cushing’s syndrome, hypothyroidism, hyperparathyroidism, pancreatic and lung cancer, myocardial infarction, Wilson’s disease, and AIDS.”

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