Patients with bipolar disorder who are insulin resistant are likely to also be refractory to mood-stabilizing treatment, according to researchers.

Martin Alda, MD of Dalhousie University, Halifax, Canada, and team note that their cross-sectional study could not prove that insulin resistance actually causes bipolar treatment resistance.

“Experimental studies will be required to determine whether normalization of glucose metabolism will affect course and treatment outcomes among patients with bipolar disorder”, they write in The British Journal of Psychiatry.

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