This randomized, controlled clinical trial compared the effect of interpersonal and social rhythm therapy to that of specialist supportive care on depressive outcomes, social functioning, and mania outcomes over 26–78 weeks in young people with bipolar disorder receiving psychopharmacological treatment.

Subjects enrolled were aged 15–36 years, recruited from a range of sources, and the patient groups included bipolar I disorder, bipolar II disorder, and bipolar disorder not otherwise specified. Outcome measures were the Longitudinal Interval Follow-up Evaluation and the Social Adjustment Scale. 

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