Unexplained painful physical symptoms are commonly reported by depressed patients. The evidence suggests that dual-action antidepressants are potent in relieving pain in depression. However, a direct comparison of the effects of selective serotonergic and selective noradrenergic antidepressants on painful symptoms has not been investigated so far.

Sixty patients who participated in the Genome-based Drugs for Depression (GENDEP) study, with a diagnosis of moderate or severe episodes of depression according to ICD-10 and DSM-IV, criteria were involved.
 

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