Certain SSRI Antidepressants Linked to Birth Defects

Impact of Depression Treatment During Pregnancy Unclear
Impact of Depression Treatment During Pregnancy Unclear
Maternal use of paroxetine (Paxil) and fluoxetine (Prozac) was associated with a higher risk of birth defects, but not with sertraline (Zoloft).

In recent years, numerous studies have reported that there may be a link between maternal use of a class of antidepressants known as selective serotonin reuptake inhibitors and greater risk of birth defects. Now, a new study provides further evidence of this association.

The study reveals that women who used certain selective serotonin reuptake inhibitors (SSRIs) for depression in early pregnancy were more likely to have offspring with heart problems and abnormal brain and skull formation, among other birth defects.

Study co-author Jennita Reefhuis, of the National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention (CDC), and colleagues publish their findings in The BMJ.

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