While people with Type I and the less-severe Type II bipolar disorder share some of the same symptoms, there are significant differences in the physical structure of their brains. Type I sufferers have somewhat smaller brain volume, researchers report in the Journal of Affective Disorders, while those with Type II appear to have less robust white matter.

Overall, there was less total brain volume — gray and white matter volume added together — and more cerebrospinal fluid volume in bipolar patients than in healthy controls, consistent with other recent studies suggesting a connection between brain volume and depression. 

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