There is variability in data relating to the safety of lithium during breastfeeding.
More frequent manic/mixed and depressive episodes were associated with an increased risk for Parkinson disease.
Given the prevalence of metabolic syndrome and insulin resistance in patients with newly diagnosed bipolar disorder, early intervention may be needed to reduce the risk for cardiovascular disease and premature death.
The FDA has approved the use of Vraylar (cariprazine; Allergan) to treat depressive episodes associated with bipolar I disorder (bipolar depression) in adults.
Infliximab-treated individuals with a childhood history of physical abuse exhibited reductions in depressive symptom scores.
Children with pediatric bipolar disorder had a larger late positive potential for happy faces compared with healthy controls.
Parkinsonism is a lesser known debilitating adverse effect associated with valproate, especially in older patients.
Concomitant use of lithium and antipsychotics, particularly haloperidol, may be associated with neurotoxicity in some patients.
The unaffected siblings of patients with bipolar disorder have increased risks for dyslipidemia and ischemic stroke.
Generalized fractional anisotropy reductions in bundles connecting regions involved in mood regulation and motor function were seen in patients with schizophrenia and bipolar disorder.