While antidepressants and psychotherapy have helped many women with postpartum depression (PPD), established pharmacologic approaches for MDD do not target the proposed mechanisms of PPD, and studies have shown that a substantial number of patients with PPD do not achieve remission with antidepressants. We interviewed 3 experts on the subject.
The ENGAGE-2 Mechanistic Pilot trial was a randomized clinical trial conducted at the University of Illinois at Chicago and Stanford University between 2019 and 2020.
This study recruited individuals with BD via advertisements on social media and through the Collaborative RESearch Team to study psychosocial issues in Bipolar Disorder (CREST.BD) website and its mailing list.
Nearly half of adults newly diagnosed with bipolar disorder are treated with mood stabilizers and/or antidepressants. Few of them initially received guideline-recommended therapy.
Patients with treatment-resistant major depressive disorder or bipolar disorder without psychotic symptoms received intravenous infusions of 0.5 mg/kg ketamine 3 times per week for 2 weeks.
The researchers evaluated socioeconomic data from the 2011 Combining Medications to Enhance Depression Outcomes (CO-MED) study to ascertain whether social determinants affect treatment response in those with major depression.
Investigators searched the PubMed, PsycINFO, and Embase databases from inception through February 2021 for studies describing the cognitive performance of patients with bipolar disorder with and without comorbid substance abuse disorder.
