HealthDay News — Childhood-onset inflammatory bowel disease (IBD) is associated with an increased risk for psychiatric morbidity, including suicide attempt, according to a study published online Aug. 19 in JAMA Pediatrics.

Agnieszka Butwicka, M.D., Ph.D., from the Karolinska Institutet in Stockholm, and colleagues examined the risk for psychiatric morbidity in individuals with childhood-onset IBD in a population-based cohort study. Data were included for 6,464 individuals with a diagnosis of childhood-onset IBD who were compared to 323,200 matched reference individuals from the general population and 6,999 siblings of patients with IBD.

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The researchers found that 17.3 percent of individuals with IBD received a diagnosis of any psychiatric disorder during a median follow-up of nine years compared with 11.8 percent in the general population (incidence rate, 17.1 versus 11.2 per 1,000 person-years), corresponding to a hazard ratio of 1.6 and representing one additional case of psychiatric disorder per 170 person-years. IBD correlated significantly with suicide attempt, mood disorders, anxiety disorders, eating disorders, personality disorders, attention-deficit/hyperactivity disorder, and autism spectrum disorders (hazard ratios, 1.4, 1.6, 1.9, 1.6, 1.4, 1.2, and 1.4, respectively). Boys and girls had similar results. In the first year of follow-up, the hazard ratios for any psychiatric disorder were highest, but they remained significantly elevated after more than five years. In between-sibling comparisons, the results were largely confirmed.

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“Long-term psychological support should therefore be considered for patients with childhood-onset IBD,” the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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