Lee Frost spent three months in 2013 taking her son Callum for treatment in a high-pressure oxygen chamber, in hopes it would help his severe autism. Ms. Frost, frustrated by the lack of approved treatments for her son, discovered hyperbaric oxygen therapy through online research.

Callum’s ability to communicate had been limited to screaming tantrums, biting and slapping, she recalls. After receiving the therapy, which involves inhaling pure oxygen for 75 minutes at a time, Callum, now 5, is able to speak in sentences and dress himself in the morning before kindergarten, Ms. Frost says. His treatment also included dietary changes. “He still has a way to go, but the child he is today is a different child,” says Ms. Frost, who lives in White Rock, British Columbia, in Canada.

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